Zebrafish models relevant to studying central opioid and endocannabinoid systems
Autor: | Wandong Bao, Oleg A. Yakovlev, Denis B. Rosemberg, Konstantin A. Demin, Anton M. Lakstygal, Polina A. Alekseeva, Darya A. Meshalkina, Allan V. Kalueff, K. Antonova, Andrey D. Volgin, Tamara G. Amstislavskaya, Maria M. Firuleva, Cai Song, Leonardo José Gil Barcellos, Murilo S. de Abreu, Elana V. Kysil, Pavel Musienko, Ashton J. Friend |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Central Nervous System animal structures ved/biology.organism_classification_rank.species Danio Neurotransmitter systems Translational research 03 medical and health sciences 0302 clinical medicine medicine Animals Model organism Zebrafish Biological Psychiatry Pharmacology biology ved/biology fungi Neurogenesis biology.organism_classification Endocannabinoid system 030104 developmental biology Opioid Models Animal Receptors Opioid Neuroscience 030217 neurology & neurosurgery medicine.drug Endocannabinoids |
Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 86 |
ISSN: | 1878-4216 |
Popis: | The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms. |
Databáze: | OpenAIRE |
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