Functional interactions between δ- and μ-opioid receptors in rat thermoregulation
| Autor: | Johanna Kela, Claes Wahlestedt, Peter Salmi, Ulf Arvidsson |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Narcotic Antagonists Receptors Opioid mu (+)-Naloxone Body Temperature Rats Sprague-Dawley chemistry.chemical_compound Opioid receptor Naltrindole Receptors Opioid delta Internal medicine medicine Animals Injections Intraventricular Pharmacology Dose-Response Relationship Drug Naloxone Antagonist Receptor Cross-Talk Hypothermia Receptor antagonist Naltrexone Rats Endocrinology chemistry Deltorphin medicine.symptom Oligopeptides Body Temperature Regulation medicine.drug |
| Zdroj: | European Journal of Pharmacology. 458:101-106 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/s0014-2999(02)02736-x |
| Popis: | The selective delta-opioid receptor agonist deltorphin II (25.0-100.0 microg, i.c.v.) produced biphasic effects on core temperature in rats, in which hypothermia was followed by hyperthermia. Pretreatment with the selective delta-opioid receptor antagonist, naltrindole (25.0 microg, i.c.v.), blocked hypothermia produced by deltorphin II and had a tendency to potentiate the hyperthermic effect of deltorphin II. The non-selective opioid receptor antagonist naloxone (1.5 mg kg(-1), s.c.) potentiated hypothermia, and blocked hyperthermia, produced by deltorphin II (100.0 microg). Also, naloxone potentiated hypothermia produced by a lower dose of deltorphin II (25.0 microg), which did not produce hyperthermia. A similar pattern was found for the selective mu-opioid receptor antagonist, beta-funaltrexamine (5.0 microg, i.c.v.), which potentiated and blocked deltorphin II-induced hypo- and hyperthermia, respectively. The selective kappa-opioid receptor antagonist nor-binaltorphimine (20.0 microg, i.c.v.) had no effects on deltorphin II-induced temperature changes. The present results suggest that deltorphin II produces hypothermia through activation of delta-opioid receptors, whereas the hyperthermic effect of deltorphin II involves activation of mu-opioid receptors. This mu-opioid receptor stimulatory effect of deltorphin II is furthermore more pronounced than was anticipated based on the reported in vitro properties of this compound. The biphasic effect of deltorphin II implies a negative interaction between delta- and mu-opioid receptors in thermoregulation in rats. |
| Databáze: | OpenAIRE |
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