Endoplasmic reticulum–plasma membrane contact sites
| Autor: | Pietro De Camilli, Yasunori Saheki |
|---|---|
| Přispěvatelé: | Lee Kong Chian School of Medicine (LKCMedicine) |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Receptors Steroid ORAI1 Protein Gene Expression Biology Endoplasmic Reticulum Biochemistry Cell membrane 03 medical and health sciences Synaptotagmins 0302 clinical medicine medicine Homeostasis Humans Science::Medicine [DRNTU] Calcium Signaling Stromal Interaction Molecule 1 Lipid Transport Phosphatidylinositol transfer protein Calcium signaling Endoplasmic reticulum Cell Membrane Membrane Proteins STIM1 Biological Transport Extended Synaptotagmins Membrane contact site Cell biology Neoplasm Proteins Oxysterol-binding Protein (OSBP)–related Protein 030104 developmental biology medicine.anatomical_structure Eukaryotic Cells Membrane protein Calcium Carrier Proteins 030217 neurology & neurosurgery |
| Popis: | The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms direct physical contacts with all other classes of membranous organelles, including the plasma membrane (PM). A number of protein tethers that mediate these contacts have been identified, and study of these protein tethers has revealed a multiplicity of roles in cell physiology, including regulation of intracellular Ca2+ dynamics and signaling as well as control of lipid traffic and homeostasis. In this review, we discuss the cross talk between the ER and the PM mediated by direct contacts. We review factors that tether the two membranes, their properties, and their dynamics in response to the functional state of the cell. We focus in particular on the role of ER–PM contacts in nonvesicular lipid transport between the two bilayers mediated by lipid transfer proteins. |
| Databáze: | OpenAIRE |
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