The Extracellular Matrix in Skin Inflammation and Infection
| Autor: | Lisa E. Shaw, Dörte Symmank, Karin Pfisterer, Wolfgang Weninger |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
skin cell migration tissue homeostasis QH301-705.5 Inflammation Review Biology Extracellular matrix 03 medical and health sciences Human health Cell and Developmental Biology 0302 clinical medicine Physical structure medicine human Biology (General) Tissue homeostasis Cell migration Cell Biology extracellular matrix (ECM) infection Cell biology 030104 developmental biology inflammation 030220 oncology & carcinogenesis Physical stability medicine.symptom Homeostasis Developmental Biology |
| Zdroj: | Frontiers in Cell and Developmental Biology Frontiers in Cell and Developmental Biology, Vol 9 (2021) |
| ISSN: | 2296-634X |
| Popis: | The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal role in tissue homeostasis and repair. While the ECM was long thought to mostly have passive functions by providing physical stability to tissues, detailed characterization of its physical structure and biochemical properties have uncovered an unprecedented broad spectrum of functions. It is now clear that the ECM not only comprises the essential building block of tissues but also actively supports and maintains the dynamic interplay between tissue compartments as well as embedded resident and recruited inflammatory cells in response to pathologic stimuli. On the other hand, certain pathogens such as bacteria and viruses have evolved strategies that exploit ECM structures for infection of cells and tissues, and mutations in ECM proteins can give rise to a variety of genetic conditions. Here, we review the composition, structure and function of the ECM in cutaneous homeostasis, inflammatory skin diseases such as psoriasis and atopic dermatitis as well as infections as a paradigm for understanding its wider role in human health. |
| Databáze: | OpenAIRE |
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