Cellular Immune Responses to Four Doses of Percutaneous Bacille Calmette-Guerin in Healthy Adults
| Autor: | Suzanne M. Grant, David R. Jacobs, Jeffrey A. Adams, Teresa S. Ludwig, Michael L. Fitzpatrick, Greg A. Andrle, Matthew R. Offerdahl, Philip W. Lowry, Sang Nae Cho |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Cellular immunity Adolescent Dose-Response Relationship Immunologic Immunization Secondary Administration Cutaneous Lymphocyte Activation Interferon-gamma Immune system Antigen Immunity Humans Immunology and Allergy Medicine Hypersensitivity Delayed Lymphocytes Skin Tests business.industry Immunogenicity Vaccination Infectious Diseases Immunization Delayed hypersensitivity Immunology BCG Vaccine Interleukin-4 business Cell Division Follow-Up Studies |
| Zdroj: | Journal of Infectious Diseases. 178:138-146 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/515614 |
| Popis: | To explore the hypothesis that low-dose immunization might induce preferential Th1 cell immunity, 76 adults were vaccinated with one of four doses of bacille Calmette-Guérin (BCG): The doses contained very low (1.6 x 10(5) cfu), low (3.2 x 10(6) cfu), standard (1.6 x 10(8) cfu), or high (3.2 x 10(8) cfu) levels of BCG. Delayed-type hypersensitivity responses occurred 8 weeks after vaccination in 10% of persons given very low or low doses of BCG, compared with 95% and 100% of persons given standard or high doses, respectively. Lymphoproliferative responses, which were increased only for high-dose vaccinees, peaked 2 weeks after vaccination and were directed chiefly against Mycobacterium tuberculosis-secreted proteins, particularly the antigen 85 complex. Significant increases in mycobacteria-specific interferon-gamma expression were present 16 weeks after vaccination only for persons given standard or high doses of BCG. Percutaneous BCG appears capable of inducing a temporary Th1-like immune response, but standard or higher dosages are required. |
| Databáze: | OpenAIRE |
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