Co-occurrence and mutual exclusivity: what cross-cancer mutation patterns can tell us
| Autor: | Jean-Philippe Theurillat, Tiziano Bernasocchi, Francesco Bertoni, Arun M. Unni, Mark A. Rubin, Geniver El Tekle, Davide Rossi |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cancer Research Carcinogenesis Genomics Synthetic lethality Gene mutation Biology medicine.disease_cause Genome 03 medical and health sciences 0302 clinical medicine Neoplasms medicine Humans 610 Medicine & health Gene Genetics Mutation Cancer medicine.disease 030104 developmental biology Oncology 030220 oncology & carcinogenesis human activities Algorithms |
| Zdroj: | Trends in Cancer. 7:823-836 |
| ISSN: | 2405-8033 |
| DOI: | 10.1016/j.trecan.2021.04.009 |
| Popis: | Cancer is the dysregulated proliferation of cells caused by acquired mutations in key driver genes. The most frequently mutated driver genes promote tumorigenesis in various organisms, cell types, and genetic backgrounds. However, recent cancer genomics studies also point to the existence of context-dependent driver gene functions, where specific mutations occur predominately or even exclusively in certain tumor types or genetic backgrounds. Here, we review examples of co-occurring and mutually exclusive driver gene mutation patterns across cancer genomes and discuss their underlying biology. While co-occurring driver genes typically activate collaborating oncogenic pathways, we identify two distinct biological categories of incompatibilities among the mutually exclusive driver genes depending on whether the mutated drivers trigger the same or divergent tumorigenic pathways. Finally, we discuss possible therapeutic avenues emerging from the study of incompatible driver gene mutations. |
| Databáze: | OpenAIRE |
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