Diagnostic pathway of the biopsy-naïve patient suspected for prostate cancer: real-life scenario when multiparametric Magnetic Resonance Imaging is not centralized
| Autor: | F. Petta, C. Cipriani, V. Forte, S. Travaglia, M. Vittori, Valerio Iacovelli, M. Panei, M. Sperandio, Riccardo Bertolo, F. Maiorino, P. Bove, C. Marani |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Image-Guided Biopsy
Male medicine.medical_specialty IRM-mp Fusion IRM-mp/échographie Urology PIRADS 030232 urology & nephrology Prospective data Prostate biopsy 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Biopsy medicine Humans Multiparametric Magnetic Resonance Imaging Fusion Fusion Biopsy medicine.diagnostic_test business.industry Biopsie de la prostate Cognitive fusion Prostatic Neoplasms Magnetic resonance imaging Cancer de la prostate medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Settore MED/24 Radiology mpMRI business |
| Popis: | We aimed to compare the pathway including multi-parametric Magnetic Resonance Imaging (mpMRI) versus the one without mpMRI in detection of prostate cancer (PCa) when mpMRI is not centralized.January 2019-March 2020: prospective data collection of trans-perineal prostate biopsies. Group A: biopsy-naïve patients who underwent mpMRI (at any institution) versus Group B: patients who did not. Within Group A, patients were stratified into those with negative mpMRI (mpMRI-, PIRADS v2.1=1-3, with PSA density0.15 if PIRADS 3) who underwent standard biopsy (SB), versus those with positive mpMRI (mpMRI+, when PIRADS 3-5, with PSA density0.15 if PIRADS 3) who underwent cognitive fusion biopsy.Two hundred and eighty one biopsies were analyzed. 153 patients underwent mpMRI (Group A). 98 mpMRI+ underwent fusion biopsy; 55 mpMRI- underwent SB. 128 Group B patients underwent SB. Overall PCa detection rate was 52.3% vs. 48.4% (Group A vs. B, P=0.5). Non-clinically-significant PCa was detected in 7.8 vs. 13.3% (Group A vs. B, P=0.1). Among the 98 mpMRI+ Group A patients only 2 had non clinically-significant disease. In 55 mpMRI- patients who underwent SB, 10 (18.2%) had clinically-significant PCa. Prostate volume predicted detection of PCa. In Group B, age and PSA predicted PCa. Sensitivity of mpMRI was 75.0% for all PCa, 85.3% for clinically-significant PCa.Higher detection of PCa and lower detection of non-clinically-significant PCa favored mpMRI pathway. A consistent number of clinically-significant PCa was diagnosed after a mpMRI-. Thus, in real-life scenario, mpMRI- does not obviate indication to biopsy when mpMRI is not centralized.3. |
| Databáze: | OpenAIRE |
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