Surfactant therapy in neonates with respiratory failure due to haemorrhagic pulmonary oedema
| Autor: | Hiroshi Shimizu, Yunosuke Ogawa, Takasuke Amizuka, Yuichi Niida |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Pulmonary Edema Surfactant therapy Pulmonary surfactant Albumins medicine Humans Respiratory system Retrospective Studies Hemothorax Biological Products Respiratory Distress Syndrome Newborn Lung Respiratory distress business.industry Respiratory disease Infant Newborn Pulmonary Surfactants medicine.disease Surfactant protein A medicine.anatomical_structure Respiratory failure Anesthesia Pediatrics Perinatology and Child Health Phosphatidylcholines Regression Analysis Female business |
| Zdroj: | European journal of pediatrics. 162(10) |
| ISSN: | 0340-6199 |
| Popis: | We studied the clinical and biochemical factors associated with surfactant dysfunction and factors affecting the responsiveness to exogenous surfactant among 27 neonates with haemorrhagic pulmonary oedema (HPE). HPE was defined as the presence of a large amount of blood-stained lung effluent and respiratory failure which was difficult to differentiate from respiratory distress syndrome. Among the neonates, 33% had very low birth weight, 96% were preterm, 70% were delivered by caesarean section, and 44% had delivery room intubation. The onset of HPE was at 1.5±0.1 h (mean ± SEM) after birth. In 26 cases, surfactant was administered at 3.0±1.3 h after the onset of HPE. The concentrations of surfactant protein A (SP-A), disaturated phosphatidylcholine (DSPC), and albumin in the epithelial lining fluid were determined using the first lung effluent from the patients. The level of inhibitory activity against pulmonary surfactant in the effluent was determined in vitro. Surfactant inhibitory activity was associated with lower birth weight, earlier gestational age, delivery room intubation, earlier onset of HPE, and lower SP-A or DSPC concentration. A good response to exogenous surfactant, which was defined as ventilatory index |
| Databáze: | OpenAIRE |
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