Aromatic hydrocarbon receptors in mitochondrial biogenesis and function
| Autor: | Hassan Rezai Ghaleno, Antoni Sureda, Adeleh Sahebnasagh, Javad Hashemi, Saeed Azimi, Mohammadreza Safdari, Amirhosein Khoshi, Hamid Reza Khayat Kashani, Maryam Khayatkashani, Fatemeh Saghafi, Fatemeh Faramarzi, Razieh Avan, Hosseinali Soltani, Solomon Habtemariam |
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| Rok vydání: | 2021 |
| Předmět: |
Organelle Biogenesis
biology Chemistry Cell Cycle Cell Biology Mitochondrion Cell cycle Receptor tyrosine kinase Mitochondria Cell biology Evolution Molecular Crosstalk (biology) Mitochondrial biogenesis biology.protein Animals Humans Molecular Medicine Mitogen-Activated Protein Kinases Signal transduction Receptor Molecular Biology Transcription factor |
| Zdroj: | Mitochondrion. 61:85-101 |
| ISSN: | 1567-7249 |
| Popis: | Mitochondria are ubiquitous membrane-bound organelles that not only play a key role in maintaining cellular energy homeostasis and metabolism but also in signaling and apoptosis. Aryl hydrocarbons receptors (AhRs) are ligand-activated transcription factors that recognize a wide variety of xenobiotics, including polyaromatic hydrocarbons and dioxins, and activate diverse detoxification pathways. These receptors are also activated by natural dietary compounds and endogenous metabolites. In addition, AhRs can modulate the expression of a diverse array of genes related to mitochondrial biogenesis and function. The aim of the present review is to analyze scientific data available on the AhR signaling pathway and its interaction with the intracellular signaling pathways involved in mitochondrial functions, especially those related to cell cycle progression and apoptosis. Various evidence have reported the crosstalk between the AhR signaling pathway and the nuclear factor κB (NF-κB), tyrosine kinase receptor signaling and mitogen-activated protein kinases (MAPKs). The AhR signaling pathway seems to promote cell cycle progression in the absence of exogenous ligands, whereas the presence of exogenous ligands induces cell cycle arrest. However, its effects on apoptosis are controversial since activation or overexpression of AhR has been observed to induce or inhibit apoptosis depending on the cell type. Regarding the mitochondria, although activation by endogenous ligands is related to mitochondrial dysfunction, the effects of endogenous ligands are not well understood but point towards antiapoptotic effects and inducers of mitochondrial biogenesis. |
| Databáze: | OpenAIRE |
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