Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies☆
| Autor: | Giulia Bernardini, Anna Maria Salzano, Natale Figura, Giovanni Renzone, Andrea Scaloni, Annalisa Santucci, Roberta Mini |
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| Rok vydání: | 2006 |
| Předmět: |
Proteomics
Atrophic gastritis Spirillaceae Blotting Western Clinical Biochemistry Stomach Diseases Biochemistry Immunoproteomics Analytical Chemistry Bacterial Proteins Antigen Stomach Neoplasms medicine Humans Electrophoresis Gel Two-Dimensional Chromatography Helicobacter pylori biology Chemistry Stomach Cell Biology General Medicine biology.organism_classification medicine.disease digestive system diseases Lymphoma medicine.anatomical_structure immunoproteomic Immunology Adenocarcinoma Electrophoresis Polyacrylamide Gel |
| Zdroj: | Journal of chromatography. B 833 (2006): 63–79. doi:10.1016/j.jchromb.2005.12.052 info:cnr-pdr/source/autori:Mini, R; Bernardini, G; Salzano, AM; Renzone, G; Scaloni, A; Figura, N; Santucci, A/titolo:Comparative proteomics and immunoproteomics of Helicobacter pylori related to different gastric pathologies/doi:10.1016%2Fj.jchromb.2005.12.052/rivista:Journal of chromatography. B (Print)/anno:2006/pagina_da:63/pagina_a:79/intervallo_pagine:63–79/volume:833 |
| ISSN: | 1570-0232 |
| Popis: | Helicobacter pylori is a Gram-negative bacterium which causes ulcer atrophic gastritis. adenocarcinoma, or mucosa-associated lymphoid tissue lymphoma. A comparative protcomic and immunoproteomic analysis was chosen to identify the antigenic patterns of three different H. pylori strains. These strains were probed against single sera from H. pylori-positive patients affected by gastric adenocarcinoma or duodenal Ulcer. We found a quite heterogeneous antigenic pattern, both from strain and sera points of view, thus underlying both a strain- and a host-specificity. The different antigenic repertoires introduced the importance of the strain to be used for immunoblotting as a diagnostic test. (c) 2006 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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