Haemophilus influenzae Type b Reemergence after Combination Immunization

Autor: Jens U. Ruggeberg, Joanna Sheldon, Gail Balfour, Helen Liddy, Paul T. Heath, Y. Chen Lee, Nik Johnson, Mary P. E. Slack, Andrew J. Pollard, Diane Irving
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Microbiology (medical)
Haemophilus Infections
Epidemiology
health care facilities
manpower
and services
Antibody Affinity
lcsh:Medicine
chemical and pharmacologic phenomena
antibody avidity
Antibodies
Viral
Diphtheria-Tetanus-acellular Pertussis Vaccines
complex mixtures
Statistics
Nonparametric
lcsh:Infectious and parasitic diseases
medicine
antibodies
Humans
lcsh:RC109-216
Avidity
Bacterial Capsules
Haemophilus Vaccines
Vaccines
Conjugate
biology
Tetanus
business.industry
Diphtheria
Research
lcsh:R
Polysaccharides
Bacterial
Haemophilus influenzae type b
medicine.disease
bacterial infections and mycoses
Confidence interval
United Kingdom
Vaccination
carbohydrates (lipids)
Infectious Diseases
Immunization
carrier state/epidemiology
Child
Preschool
Immunology
biology.protein
bacteria
Pharynx
Antibody
business
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 12, Iss 6, Pp 937-941 (2006)
Scopus-Elsevier
ISSN: 1080-6059
1080-6040
Popis: Combination vaccines may suppress Hib antibody concentration and avidity.
An increase in Haemophilus influenzae type b (Hib) in British children has been linked to the widespread use of a diphtheria/tetanus/acellular pertussis combination vaccine (DTaP-Hib). We measured anti-polyribosyl-ribitol phosphate antibody concentration and avidity before and after a Hib booster in 176 children 2–4 years of age who had received 3 doses of DTP-Hib (either DT whole cell pertussis-Hib or DTaP-Hib) combination vaccine in infancy. We also measured pharyngeal carriage of Hib. Antibody concentrations before and avidity indices after vaccination were low (geometric mean concentration 0.46 μg/mL, 95% confidence interval [CI] 0.36–0.58; geometric mean avidity index 0.16, 95% CI 0.14–0.18) and inversely related to the number of previous doses of DTaP-Hib (p = 0.02 and p
Databáze: OpenAIRE
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