Vascular endothelial growth factor is an autocrine growth factor for hair dermal papilla cells
| Autor: | Frederic Jonca, Yvon Gall, Nadia Bouhaddioui, Marie Charveron, Jean Plouët, Jean Louis Bonafe, Hafida Moukadiri, Souad Lachgar |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty medicine.medical_treatment Dermatology Endothelial Growth Factors Biology Biochemistry chemistry.chemical_compound Internal medicine Skin Physiological Phenomena medicine Animals Growth factor receptor inhibitor Molecular Biology Cells Cultured Skin Lymphokines integumentary system Vascular Endothelial Growth Factors Growth factor Cell Biology Immunohistochemistry Cell biology Rats Major duodenal papilla Vascular endothelial growth factor B Vascular endothelial growth factor Vascular endothelial growth factor A Dermal papillae medicine.anatomical_structure Endocrinology chemistry Vascular endothelial growth factor C Mitogens Hair Follicle Cell Division |
| Zdroj: | The Journal of investigative dermatology. 106(1) |
| ISSN: | 0022-202X |
| Popis: | The transition of the late anagen to the catagen phase is concomitant with the disappearance of perifollicular capillaries, and therefore cyclical hair growth might depend on the ability of the dermal papilla to synthesize and release soluble growth and differentiation factors toward pre-existing capillaries. We characterized an angiogenic growth factor in the conditioned medium of dermal papilla cells indistinguishable from vascular endothelial growth factor as judged by biochemical and immunologic criteria. In addition, these cells bind vascular endothelial, growth factor on two binding sites and proliferate or migrate in the presence of this growth factor. Moreover, neutralizing antibodies inhibit these biologic effects, confirming that vascular endothelial growth factor might contribute to hair growth either by acting directly on papilla cells or by stimulating the local vascularization. |
| Databáze: | OpenAIRE |
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