Single center experience with intralesional bleomycin sclerotherapy for lymphatic malformations
| Autor: | Hakan Yılmaz, Ümit Belet, Özlem Yılmaz, Hüseyin Akan, İlkay Çamlıdağ |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi, Hitit Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Percutaneous Erythema Adolescent medicine.medical_treatment Macrocystic Injections Intralesional Radiology Interventional Single Center Bleomycin 030218 nuclear medicine & medical imaging 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Sclerotherapy Medicine Humans Radiology Nuclear Medicine and imaging Lymphatic malformation Child Retrospective Studies Antibiotics Antineoplastic Lymphatic Abnormalities medicine.diagnostic_test business.industry Infant Newborn Infant Interventional radiology Retrospective cohort study Surgery Lymphatic Malformation Lymphatic system Treatment Outcome chemistry 030220 oncology & carcinogenesis Child Preschool Female Radiology medicine.symptom business |
| DOI: | 10.1007/s11604-017-0672-5 |
| Popis: | Purpose: The purpose of our study was to evaluate the efficacy of percutaneous sclerotherapy using bleomycin in treatment of lymphatic malformations. Methods: Between January 2009 and January 2013, ten patients with lymphatic malformations who were admitted to the interventional radiology department were included in this retrospective study. Intralesional bleomycin was administered by percutaneous injection through 21–23 Gauge needles with a dose of 1 mg/kg body weight. Patients were clinically and radiologically assessed at baseline and followed at first and third months after treatment. Response to treatment was measured visually by using photographs and by radiological images. Symptomatic improvement was also evaluated either by patients or parents. Results: Excellent resolution was obtained visually in 80% of patients with lymphatic malformation. Significant resolution was achieved in 20% of patients. The percentage of radiographic resolution in size and the improvement in symptoms evaluated by patients or parents were similar with visual outcomes. No side effects were recorded except for fever in one patient and transient erythema in another patient. Conclusion: Intralesional bleomycin is a safe and effective treatment for patients with lymphatic malformations. © 2017, Japan Radiological Society. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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