Retarded recovery of functional T cell frequencies in T cell-depleted bone marrow transplant recipients

Autor:	J P, Daley, M K, Rozans, B R, Smith, S J, Burakoff, J M, Rappeport, R A, Miller
Rok vydání:	1987
Předmět:	Time Factors T-Lymphocytes Immunology Humans Bone Marrow Cells Postoperative Period Cell Biology Hematology Biochemistry Cell Division Lymphocyte Depletion Bone Marrow Transplantation T-Lymphocytes Cytotoxic
Zdroj:	Blood. 70:960-964
ISSN:	1528-0020 0006-4971
Popis:	We have studied the effect of removing donor T cells by treatment with the monoclonal antibody Leu-1 and complement before marrow transplantation on the regeneration of functionally competent T lymphocytes in the blood at selected times after transplant. Using sensitive limiting-dilution methods that allow us to enumerate helper, cytotoxic, and proliferating T lymphocyte precursors, we report that regeneration of a functional T cell compartment is more severely impaired for the first 180 days after transplantation in those patients given T cell-depleted bone marrow than in recipients of untreated marrow. After this first 6 months, however, patients given T cell- depleted bone marrow had blood T cell frequencies comparable to those observed in patients given untreated marrow. Diminished frequencies of reactive T cells in recipients of depleted marrow could leave them more susceptible to infection or to the recurrence of neoplastic cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3316f69b9bab9246abe4b462ad3218 https://doi.org/10.1182/blood.v70.4.960.bloodjournal704960 Zobrazit plný text záznamu