Apolipoprotein E ε4 allele effects on longitudinal cognitive trajectories are sex and age dependent
| Autor: | Nicole M. Armstrong, Yang An, Luigi Ferrucci, Susan M. Resnick, Andrea T. Shafer, Jessica Helphrey, Owen A. Williams, Melissa H. Kitner-Triolo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Apolipoprotein E
Male Epidemiology Apolipoprotein E4 Age dependent Neuropsychological Tests 050105 experimental psychology White People Article 03 medical and health sciences Cellular and Molecular Neuroscience Executive Function 0302 clinical medicine Sex Factors Developmental Neuroscience Memory Medicine Humans 0501 psychology and cognitive sciences Longitudinal Studies Allele Cognitive decline Baseline (configuration management) Alleles Aged business.industry Health Policy 05 social sciences Age Factors Cognition Psychiatry and Mental health lipids (amino acids peptides and proteins) Female Neurology (clinical) Geriatrics and Gerontology business Cognition Disorders 030217 neurology & neurosurgery Demography |
| Zdroj: | Alzheimers Dement |
| ISSN: | 1552-5279 |
| Popis: | INTRODUCTION: Questions remain about whether APOE-ε4 effects on cognitive decline are similar in men and women and how APOE-ε4 and age interact to influence decline in different cognitive domains. METHODS: In sex stratified analyses, age-dependent associations between APOE-ε4 status and longitudinal cognitive trajectories were examined in cognitively normal older adults (631 men, 561 women, baseline age range: 50–93, 6733 assessments). Where age-dependent relationships were found, age of divergence in trajectories for APOE genotypes was estimated. RESULTS: In men, APOE-ε4 had significant age-dependent effects on longitudinal decline in memory and executive function detectible from baseline age of 64 and 68, respectively. In women, APOE-ε4 had a significant age-dependent effect on longitudinal decline in attention detectible at baseline age of 66. No significant APOE-ε4 effects were found for language, visual-spatial ability or processing speed. DISCUSSION: Results highlight the importance of considering sex and age when assessing APOE-ε4 associated vulnerability to cognitive decline. |
| Databáze: | OpenAIRE |
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