Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson's disease
| Autor: | Fen Wang, An-Mu Xie, Ling-Xi Li, Chun-Feng Liu, Dong-Jun Lv, Shi-Zhuang Wei, Hua Hu, Jing Chen |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Parkinson's disease Dopamine Emotions Disease Motor Activity 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound 0302 clinical medicine Cognition Memory Internal medicine Rotenone Medicine Animals Zebrafish 030304 developmental biology 0303 health sciences biology business.industry Parkinson Disease medicine.disease biology.organism_classification Sleep in non-human animals Sleep deprivation Disease Models Animal Endocrinology chemistry 3 4-Dihydroxyphenylacetic Acid Sleep Deprivation medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Behavioural brain research. 372 |
| ISSN: | 1872-7549 |
| Popis: | Parkinson’s disease (PD) is the second most common neurodegenerative disorder in the world. Apart from motor deficits, PD reduces patient’s quality of life through sleep disturbances, cognitive impairment and emotional disorders. However, it’s unclear whether bad life habits such as stay up late exacerbate the patient’s cognition and emotional disorders. Thus we investigated the consequences of sleep deprivation (SD) on memory and emotions using a rotenone-based zebrafish model of PD. Behavioral assays, using locomotor activity assay, showed that rotenone treated zebrafish exhibited PD-like symptoms, whereas sleep deprivation didn’t exacerbate the progression of them. The object discrimination task exhibited that the short-term cognitive deficits of rotenone group are more serious than the sham group after SD. Light-dark box test showed that rotenone treated fish are more dysphoric than the sham fish after SD. Dopamine and DOPAC significantly reduced in rotenone treated fish compared with the sham fish. However, this DOPAC reduction recovered after SD. The expression of D2 and D3 in rotenone treated zebrafish elevated compared with sham group and SD group. However, the rotenone treated zebrafish manifested a decrease level of D2 and D3 after SD. D1 did not show any significantly changes among the four groups. Our findings suggest that zebrafish treated with rotenone may have a more severe damage of memory and emotional function after SD, which may be related to the changes in the DA systems. |
| Databáze: | OpenAIRE |
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