Intravenous Gamma Globulin for Thrombocytopenia in Children with Evans Syndrome
Autor: | Winfred C. Wang, Rachelle Nuss |
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Rok vydání: | 1987 |
Předmět: |
Male
medicine.medical_specialty Vincristine Evans syndrome Adolescent Cyclophosphamide Anemia medicine.medical_treatment Splenectomy Gastroenterology Immune Hemolytic Anemia Internal medicine Humans Medicine biology business.industry Gamma globulin Syndrome Hematology medicine.disease Thrombocytopenia Oncology Pediatrics Perinatology and Child Health Immunology biology.protein Female Anemia Hemolytic Autoimmune gamma-Globulins Antibody business medicine.drug |
Zdroj: | Journal of Pediatric Hematology/Oncology. 9:164-167 |
ISSN: | 1077-4114 |
Popis: | We describe three patients with Evans syndrome (immune hemolytic anemia and immune thrombocytopenia) who were refractory to conventional therapy, including steroids and splenectomy in all of the patients, vincristine in two, and cyclophosphamide in one. The patients were then treated with modified intravenous gamma globulin 0.4 g/kg/day for 5 consecutive days. Two patients failed to respond, but the third had a clinical remission after gamma globulin therapy. Given the usual chronic and relapsing course of Evans syndrome and the poor response to conventional therapy, we recommend that high dose i.v. gamma globulin be considered an alternative therapy in the management of these patients. |
Databáze: | OpenAIRE |
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