Long-pulsed neodymium-doped yttrium-aluminum-garnet laser versus cryotherapy for the treatment of cutaneous warts: A randomized controlled trial

Autor: Shichao Lu, Hongtian Li, Jun-lian Liu, Tian-bao Xia, Zhi-hao Cheng, Yingyun Ren, Xiaojia Cao, Fan Yang, Jian-jun Liu
Rok vydání: 2022
Předmět:
Zdroj: Journal of the American Academy of Dermatology. 87:1328-1335
ISSN: 0190-9622
DOI: 10.1016/j.jaad.2020.09.085
Popis: Background Observational studies have shown promising therapeutic effects of long-pulsed neodymium-doped yttrium aluminum garnet (LP-Nd:YAG) laser on warts. Objective To evaluate whether LP-Nd:YAG laser was superior to cryotherapy for cutaneous warts. Methods In this study, 150 adult patients with warts were randomized equally to receive laser or cryotherapy every 3–4 weeks, a maximum of 4 sessions. The primary outcomes were cure rate at 16 weeks and 6 months; secondary outcomes included time to clearance of warts and treatment-related adverse effects. Results There was no difference in the cure rate for laser versus cryotherapy at 16 weeks (54.1% vs. 46.7%) and 6 months (59.5% vs. 57.3%). However, time to clearance of warts, up to 16 weeks and 6 months, tended to be shorter for laser versus cryotherapy ( P = .04 and .08, respectively). Post-hoc analyses showed a significantly higher cure rate for laser versus cryotherapy in 3 subgroups of HPV 2/27/57-induced recalcitrant warts, but not in their counterpart subgroups. Laser had more mild adverse effects. Limitations Single-center. Conclusions The overall therapeutic effects of LP-Nd:YAG laser were similar to cryotherapy, but laser may be more effective to relatively recalcitrant warts and may associate with shorter time to clearance of warts.
Databáze: OpenAIRE
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