Studies on the Subcutaneous Absorption in Mice VIII: Influence of Connective Tissue Ground Substance on the Absorption of Subcutaneously Injected Depots of Sodium and Chloride
| Autor: | E. Secher‐Hansen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Radioisotope Dilution Technique medicine.medical_specialty Depot Injections Subcutaneous Sodium Connective tissue chemistry.chemical_element Absorption (skin) Toxicology Chloride Absorption Mice Subcutaneous injection Chlorides Internal medicine medicine Animals Radioisotopes Pharmacology Subcutaneous Absorption Chemistry Radiochemistry Ground substance Water-Electrolyte Balance medicine.anatomical_structure Endocrinology Connective Tissue Sodium Isotopes medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 28:102-107 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1970.tb00534.x |
| Popis: | A standard volume of 80 μl of physiological saline or of pure water was injected subcutaneously in mice. In both cases the electrolyte composition of the depots was the same 15 minutes later, at which time the injected volumes had not been significantly reduced. The sodium concentration in the depot corresponded to that of the plasma, while the chloride concentration corresponded to approximately 50 per cent of that of the plasma. The missing anions could probably be accounted for by the non-diffusible polyanions of the connective tissue ground substance. Radioactive sodium ions were cleared significantly more slowly than radioactive chloride ions, these in turn being significantly slower than the radioactive water molecules, after the subcutaneous injection of physiological saline or water depots containing the radioactive ions in tracer concentrations. |
| Databáze: | OpenAIRE |
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