Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis
| Autor: | SM Bentzen, I Balslev, M Pedersen, PS Teglbjaerg, F Hanberg-Sørensen, J Bone, NO Jacobsen, A Sell, J Overgaard, K Bertelsen, E Hage, C Fenger, O Kronborg, L Hansen, H Høtrup, B Nørgaard-Pedersen |
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| Jazyk: | angličtina |
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Multivariate analysis Time Factors Colorectal cancer medicine.medical_treatment Perineural invasion Rectum Gastroenterology Carcinoembryonic antigen Recurrence Internal medicine Carcinoma Medicine Humans Aged Neoplasm Staging biology business.industry Proportional hazards model Rectal Neoplasms Middle Aged medicine.disease Combined Modality Therapy Surgery Radiation therapy medicine.anatomical_structure Oncology Colonic Neoplasms Multivariate Analysis biology.protein Regression Analysis Female Neoplasm Recurrence Local business Research Article Follow-Up Studies |
| Zdroj: | Bentzen, S M, Balslev, I, Pedersen, M, Teglbjaerg, P S, Hanberg-Sørensen, F, Bone, J, Jacobsen, N O, Sell, A, Overgaard, J, Bertelsen, K, Hage, E, Fenger, C, Kronborg, O, Hansen, L, Høstrup, H & Nørgaard-Pedersen, B 1992, ' Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis ', B J C, vol. 65, no. 1, pp. 102-107 . < http://www.ncbi.nlm.nih.gov/pubmed/?term=1733432 > British Journal of Cancer |
| Popis: | Factors influencing time to loco-regional recurrence were identified in a multivariate regression analysis of data from a series of 468 radically operated patients (260 Dukes' B and 208 Dukes' C) with carcinoma of the rectum and the rectosigmoid. A number of clinical and pathological characteristics were prospectively collected and recorded. In addition, carcinoembryonic antigen (CEA) was measured within 1 week before surgery. The endpoint used was recurrence below the level of the umbilicus. All patients were followed for at least 5 years or until time of death. The two Dukes' stages B and C were analysed in two separate analyses using the Cox proportional hazards model. In patients with Dukes' B tumours, an increased risk of loco-regional recurrence was associated with perineural invasion, tumour located less than 10 cm from the anal verge, patient aged above 70 years, and small tumour size. In patients with Dukes' C tumours, the necessity to resect neighbour organs, perineural and venous invasion, tumour located less than 10 cm from the anal verge, and large tumour size were all associated with a poor loco-regional outcome. Postoperative radiotherapy was not a significant prognosticator for loco-regional control. An update of the 5-year results of the randomised study of post-operative radiotherapy (50 Gy with 2 Gy per fraction in an overall treatment time of 7 weeks) showed no survival benefit from adjuvant radiotherapy in either Dukes' category and no statistically significant improvement in the 5-year loco-regional control rate. However, when the comparison was restricted to a group of high-risk patients there was a statistically significant benefit from radiotherapy with respect to loco-regional control (P = 0.03) but not with respect to survival (P = 0.23). The potential advantage, in terms of the required number of patients, of restricting clinical trials of intensified loco-regional therapies to the high-risk patients, is illustrated. |
| Databáze: | OpenAIRE |
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