Retrospective cohort study comparing the outcomes of intravenous busulfan vs. total-body irradiation after single cord blood transplantation
| Autor: | Juan Tong, Jianjun Li, Changcheng Zheng, Xiang Wan, Siguo Hao, Xiaoliang Liu, Liangquan Geng, Guangyu Sun, Baolin Tang, Xinquan Liang, Nainong Li, Lei Zhang, Zimin Sun, Zhonglin Wei, Xiaoyu Zhu, Xingbing Wang, Kaiyang Ding, Wen Yao, Kai-Di Song, Huilan Liu, Yun Wu, Sujun Gao, Dongjun Lin, Xuhan Zhang, Lulu Huang, Dong-Ping Huang |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Gastroenterology Cohort Studies Young Adult Internal medicine Humans Medicine Cumulative incidence Child Busulfan Retrospective Studies Transplantation Neutrophil Engraftment business.industry Umbilical Cord Blood Transplantation Hazard ratio Retrospective cohort study Hematology Middle Aged Total body irradiation Treatment Outcome Cohort Administration Intravenous Female Cord Blood Stem Cell Transplantation business Whole-Body Irradiation Cohort study |
| Zdroj: | Bone Marrow Transplantation. 54:1614-1624 |
| ISSN: | 1476-5365 0268-3369 |
| DOI: | 10.1038/s41409-019-0441-4 |
| Popis: | Limited to inadequate stem-cell doses, cord blood transplantation (UCBT) is accompanied by increased graft failure and delayed haematopoietic recovery. The conditioning regimen is critically important for engraftment, and numerous trials have been undertaken comparing the outcomes of IV Bu and TBI, but there are no comparative data for UCBT. We conducted a retrospective multicentre study to analyse the outcomes of IV Bu and TBI in UCBT patients with haematologic malignancies. Between 1 May, 2008 and 31 Mar, 31 2018, a total of 331 patients from the China Umbilical Cord Blood Transplantation Corporation (IV Bu, n = 131; TBI, n = 200) were evaluated. The cumulative incidence of neutrophil engraftment was 91.6% in the IV Bu/Cy cohort and 98.0% in the Cy/TBI cohort (P |
| Databáze: | OpenAIRE |
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