Multiple Pathways Transmit Neuroprotective Effects of Gonadal Steroids
| Autor: | Daniel M. Dorsa, Damani N. Bryant, Robert A. Shapiro, L. C. Sheldahl, Lisa K. Marriott |
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| Rok vydání: | 2006 |
| Předmět: |
MAPK/ERK pathway
medicine.drug_class Endocrinology Diabetes and Metabolism Pharmacology Biology Models Biological Neuroprotection Endocrinology Transcription (biology) medicine Animals Regulatory Elements Transcriptional Gonadal Steroid Hormones Protein kinase B Protein kinase C Sex Characteristics Estradiol Estrogen Replacement Therapy Disease progression Membrane Proteins Neuroprotective Agents Gene Expression Regulation Receptors Estrogen Estrogen Brain Injuries Nervous System Diseases Signal transduction Protein Processing Post-Translational Neuroscience hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Endocrine. 29:199-208 |
| ISSN: | 0969-711X |
| Popis: | Numerous preclinical studies suggest that gonadal steroids, particularly estrogen, may be neuroprotective against insult or disease progression. This paper reviews the mechanisms contributing to estrogen-mediated neuroprotection. Rapid signaling pathways, such as MAPK, PI3K, Akt, and PKC, are required for estrogen's ability to provide neuroprotection. These rapid signaling pathways converge on genomic pathways to modulate transcription of E2-responsive genes via ERE-dependent and ERE-independent mechanisms. It is clear that both rapid signaling and transcription are important for estrogen's neuroprotective effects. A mechanistic understanding of estrogen-mediated neuroprotection is crucial for the development of therapeutic interventions that enhance quality of life without deleterious side effects. |
| Databáze: | OpenAIRE |
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