Effects of α-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with ammonium acetate
Autor: | K.B. Dakshayani, Velvizhi S, Perumal Subramanian |
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Rok vydání: | 2002 |
Předmět: |
Male
Antioxidant Nitrogen Endocrinology Diabetes and Metabolism medicine.medical_treatment Acetates Kidney Thiobarbituric Acid Reactive Substances Antioxidants Superoxide dismutase Lipid peroxidation Random Allocation chemistry.chemical_compound medicine Animals Hyperammonemia Urea Rats Wistar chemistry.chemical_classification Nutrition and Dietetics biology Chemistry Glutathione peroxidase Body Weight Kidney metabolism Organ Size Glutathione Lipids Rats Liver Biochemistry Catalase biology.protein Ketoglutaric Acids Lipid Peroxidation Ammonium acetate |
Zdroj: | Nutrition. 18:747-750 |
ISSN: | 0899-9007 |
DOI: | 10.1016/s0899-9007(02)00825-0 |
Popis: | The effects of alpha-ketoglutarate (alpha-KG) on hyperammonemia induced by ammonium acetate were studied biochemically in experimental rats. The levels of circulatory urea and non-protein nitrogen increased significantly in rats treated with ammonium acetate and decreased significantly in rats treated with alpha-KG and ammonium acetate. In liver and kidney tissues, similar patterns of alterations across groups were observed in the levels of thiobarbituric acid-reactive substances and lipid profile variables (free fatty acids, triacylglycerols, phospholipids, and cholesterol). Further, enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic (reduced glutathione) antioxidants in both tissues decreased significantly in rats treated with ammonium acetate and increased significantly in rats treated with alpha-KG and ammonium acetate. The biochemical alterations during alpha-KG treatment might have been due to 1) the detoxification of excess ammonia, 2) participation in the non-enzymatic oxidative decarboxylation during hydrogen peroxide decomposition, and 3) enhancement of the proper metabolism of fats that could suppress oxygen radical generation and thus prevent lipid peroxidative damages in rats. |
Databáze: | OpenAIRE |
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