Correlation of the Ga-68-Bombesin Analog Ga-68-BZH3 with Receptors Expression in Gliomas as Measured by Quantitative Dynamic Positron Emission Tomography (dPET) and Gene Arrays

Autor: Caixia Cheng, Marcel Seiz, Kirsten Schmieder, Ludwig G. Strauss, Jochen Tuettenberg, Antonia Dimitrakopoulou-Strauss, Dirk Koczan, Leyun Pan
Rok vydání: 2011
Předmět:
Zdroj: Molecular Imaging and Biology. 14:376-383
ISSN: 1860-2002
1536-1632
DOI: 10.1007/s11307-011-0508-0
Popis: The kinetics of Ga-68-BZH3, a Ga-68-bombesin analog, was compared to molecular biological data obtained from gene arrays in seven patients with a recurrent glioma. The primary aim of this study was the correlation of receptor expression and tracer kinetics.Dynamic positron emission tomography studies were performed and the data were analyzed by a volume-of-interest technique using a two-tissue compartment model as well as a non-compartment model. Gene array data were obtained from gene array analysis of tumor tissue samples.The correlation analysis revealed a significant nonlinear correlation of r = 0.89 (p 0.03) for k1 and BB(2) (gastrin-releasing peptide receptor). BB(1) and BB(3) were not significantly correlated with k1. vb and k3 were not significantly correlated with the expression data of the receptors on the p 0.05 level.The parameter k1 is correlated with the expression of BB(2) based on gene array data. The quantitative analysis of the Ga-68-BZH3 kinetics can be used to predict the receptor expression of BB(2) in gliomas based on k1 of the compartment analysis. However, this study is limited to the expression data on the mRNA level and further studies are needed to assess the correlation of gene expression on the protein level.
Databáze: OpenAIRE
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