Post‐reflux swallow‐induced peristaltic wave is impaired in laryngopharyngeal and gastro‐oesophageal reflux disease
| Autor: | Jin-soo Park, Gregory L. Falk, Hans Van der Wall |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Esophageal pH Monitoring Physiology Disease Gastroenterology Laryngopharyngeal reflux Gastro Physiology (medical) Internal medicine Electric Impedance otorhinolaryngologic diseases medicine Humans In patient Peristalsis business.industry digestive oral and skin physiology Reflux Heartburn General Medicine medicine.disease digestive system diseases Gastroesophageal Reflux medicine.symptom business Area under the roc curve |
| Zdroj: | Clinical Physiology and Functional Imaging. 42:8-14 |
| ISSN: | 1475-097X 1475-0961 |
| DOI: | 10.1111/cpf.12729 |
| Popis: | INTRODUCTION Laryngopharyngeal reflux (LPR) and gastro-oesophageal reflux disease (GORD) result from the reflux of gastric contents. The post-reflux swallow-induced peristaltic wave (PSPW) is an oesophageal reflex that facilitates chemical clearance of gastric contents following reflux events. PSPW index is a novel parameter that has been validated in assessing the effectiveness of chemical clearance in GORD, but not in LPR. This study aimed to assess chemical clearance in LPR and GORD by measuring PSPW indices in a consecutive series of patients. METHODS Reviewers blindly analysed off-therapy impedance-pH tracings from 187 patients clinically categorized as LPR (n = 105) or GORD (n = 82) by predominant symptom profile. Conventional impedance-pH measures and PSPW indices were analysed. RESULTS Mean PSPW index in the LPR group was higher than in the GORD group (39.7% (±17.7%) vs. 20.6% (±13.4%); p |
| Databáze: | OpenAIRE |
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