Variation among Pathologists in the Histologic Grading of Canine Cutaneous Mast Cell Tumors with Uniform Use of a Single Grading Reference
| Autor: | Tracy L. Gieger, Nicole C. Northrup, Lauren J. Richey, Cathy A. Brown, Anapatricia Garcia, Nancy L. Stedman, Kenneth S. Latimer, E. W. Howerth, Pauline M. Rakich, Barry G. Harmon, John S. Munday, K. P. Carmicheal |
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| Rok vydání: | 2005 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Mastocytosis Cutaneous 040301 veterinary sciences Mast cell tumors 0403 veterinary science 03 medical and health sciences Dogs medicine Tumor Grading Animals Dog Diseases Grading (tumors) Reference standards Observer Variation General Veterinary business.industry Reproducibility of Results Mastocytoma 04 agricultural and veterinary sciences Prognosis medicine.disease digestive system diseases 030104 developmental biology Histopathology Observer variation business |
| Zdroj: | Journal of Veterinary Diagnostic Investigation. 17:561-564 |
| ISSN: | 1943-4936 1040-6387 |
| Popis: | Ten veterinary pathologists independently assigned histologic grades to the same 60 canine cutaneous mast cell tumors using the Patnaik classifications. The degree of agreement in grading among the pathologists was compared with the degree of agreement among the same pathologists in a previous study, in which each pathologist used the reference for grading that he/she uses routinely. Mean agreement improved significantly from 50.3% to 62.1% with uniform use of the Patnaik classifications ( P = 0.00001), suggesting that there is value in uniform application of a single grading scheme for canine cutaneous mast cell tumors. Agreement among pathologists was still not 100%, suggesting that a more objective grading scheme should be developed and that other histologic indicators of prognosis should be investigated. |
| Databáze: | OpenAIRE |
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