The posthatch prophylactic use of ceftiofur affects the cecal microbiota similar to the dietary sanguinarine supplementation in broilers
| Autor: | Oliveiro C. Freitas Neto, Celso José Bruno de Oliveira, Patrícia Emília Naves Givisiez, P. F. Giachetto, Mauro M.S. Saraiva, Núbia Michelle Vieira da Silva, Wondwossen A. Gebreyes, Mateus P.L. Lemos, P.F.C. Vasconcelos, Elma Lima Leite |
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| Přispěvatelé: | MATEUS P. L. LEMOS, CCA/UFPB, MAURO M. S. SARAIVA, CCA/UFPB, ELMA L. LEITE, CCA/UFPB, NÚBIA M. V. SILVA, CCA/UFPB, PRISCYLLA C. VASCONCELOS, CCA/UFPB, POLIANA FERNANDA GIACHETTO, CNPTIA, OLIVEIRO C. FREITAS NETO, UFMG, PATRÍCIA E. N. GIVISIEZ, CCA/UFPB, WONDWOSSEN A. GEBREYES, The Ohio State University, Columbus, CELSO J. B. OLIVEIRA, CCA/UFPB, The Ohio State University, Columbus. |
| Rok vydání: | 2020 |
| Předmět: |
RNA
Ribosomal 16S cecal microbiota Food science Cecum lcsh:SF1-1100 Aplicação profilática pós-parto 0303 health sciences Análise Estatística Broiler Bioinformática Biodiversity 04 agricultural and veterinary sciences General Medicine Enterobacteriaceae Frango de Corte Anti-Bacterial Agents Frango Statistical analysis Ceftiofur Bioinformatics Firmicutes Feed additive Biology broiler 03 medical and health sciences Antibiotic resistance Animals Microbiology and Food Safety 16S rRNA 030304 developmental biology Benzophenanthridines Sanguinarine Lachnospiraceae 0402 animal and dairy science Isoquinolines biology.organism_classification Animal Feed 040201 dairy & animal science ceftiofur Cephalosporins Diet Gastrointestinal Microbiome Broiler chickens Animals Newborn Cecal microbiota Dietary Supplements Animal Science and Zoology lcsh:Animal culture Bacteroides Chickens sanguinarine |
| Zdroj: | Poultry Science Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA Poultry Science, Vol 99, Iss 11, Pp 6013-6021 (2020) |
| ISSN: | 0032-5791 |
| Popis: | The prophylactic administration of ceftiofur to newly hatched chicks is a common practice in some hatcheries worldwide to mitigate early gastrointestinal infections caused by Enterobacteriaceae. In spite of the crucial role of the gut microbiome for the broiler's health, there is still limited information on how the microbial composition is affected by such procedure. We investigated the effects of posthatch prophylactic application of ceftiofur on the cecal microbiota of 14-day-old broilers fed regular or sanguinarine-supplemented diets. DNA samples were extracted from cecal contents, amplified for the V3-V4 regions of the microbial 16S rRNA gene, and sequenced in a high-throughput sequencing platform (Illumina MiSeq). After downstream bioinformatics and statistical analyses, our results demonstrated that both ceftiofur and sanguinarine treatments similarly increased the proportions of the phylum Bacteroidetes and the genera Bacteroides and Megamonas, whereas reduced the relative abundances of Firmicutes and Lachnospiraceae in the ceca of the birds. Such changes are probably associated with increased carbohydrate fermentation processes favoring the production of short-chain fatty acids. This was also corroborated by the functional prediction findings, which suggest an increase in some metabolic pathways associated with digestibility in broilers receiving ceftiofur. Considering that antimicrobial stewardship in animal production systems is strongly needed to mitigate the threat of antimicrobial resistance, our findings show that supplementation with a phytogenic feed additive can lead to a similar microbial composition in the ceca of commercial broiler chickens, suggesting that the use of alternative products could lead to functional modifications without increasing pressure for antimicrobial resistance. Made available in DSpace on 2020-11-07T09:14:39Z (GMT). No. of bitstreams: 1 AP-Posthatch-prophylactic-2020.pdf: 1523214 bytes, checksum: 814d02246982ec61f3cacd90fae08f0d (MD5) Previous issue date: 2020 |
| Databáze: | OpenAIRE |
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