Use of an enzyme immunoassay for detection of antibody to human immunodeficiency virus in low risk populations
| Autor: | Frans Peetoom |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Immunology
Human immunodeficiency virus (HIV) Blood Donors HIV Antibodies medicine.disease_cause Antibodies Viral Virus Immunoenzyme Techniques medicine Immunology and Allergy Humans chemistry.chemical_classification Acquired Immunodeficiency Syndrome Clinical Trials as Topic biology medicine.diagnostic_test HIV Genetic systems Hematology Virology Predictive value United States Enzyme chemistry Immunoassay biology.protein Plasma donor Antibody |
| Zdroj: | Transfusion. 26(6) |
| ISSN: | 0041-1132 |
| Popis: | Antibody to Human Immunodeficiency Virus (HIV) was detected by an enzyme immunoassay (Genetic Systems LAV EIA) in low risk populations from five geographically distinct sites. The assay used virus (LAV) grown in the T-cell line CEM. In blood and plasma donor populations, 0.4 percent of the samples were initially reactive and 0.2 percent were repeatably reactive. Fourteen of the twenty-one (67 percent) repeatably reactive specimens were confirmed by immuneprecipitation (RIP). The assay demonstrated 99.9 percent specificity compared to RIP and had a positive predictive value of 67 percent. The data suggest that this test generates a low proportion of false positive EIA results and is highly suitable to screen blood donors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text