LncRNA MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis
| Autor: | Liang Tang, Yu Xiao, Li Wang, Yucheng Bao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
lcsh:Diseases of the musculoskeletal system Proliferation Down-Regulation Apoptosis Osteoarthritis Cell Line 03 medical and health sciences Chondrocytes 0302 clinical medicine lcsh:Orthopedic surgery medicine Humans lncRNA MIR4435-2HG Orthopedics and Sports Medicine Chondrocyte cell proliferation Lung cancer Gene Aged 030203 arthritis & rheumatology 030222 orthopedics Gene knockdown Microarray analysis techniques business.industry Cancer Middle Aged medicine.disease lcsh:RD701-811 MicroRNAs Cancer research Female RNA Long Noncoding Surgery lcsh:RC925-935 business Biomarkers Research Article |
| Zdroj: | Journal of Orthopaedic Surgery and Research Journal of Orthopaedic Surgery and Research, Vol 14, Iss 1, Pp 1-5 (2019) |
| ISSN: | 1749-799X |
| DOI: | 10.1186/s13018-019-1278-7 |
| Popis: | Purpose MIR4435-2HG is an oncogenic lncRNA in gastric cancer and lung cancer. Our preliminary microarray data showed that MIR4435-2HG was downregulated in osteoarthritis plasma specimen, indicating the possible involvement of MIR4435-2HG in osteoarthritis. Results MIR4435-2HG was downregulated in plasma of osteoarthritis than in plasma of healthy controls. Reduced levels of MIR4435-2HG expression effectively distinguished osteoarthritis patients from the control group. Expression levels of MIR4435-2HG increased after treatment. Overexpression of MIR4435-2HG promoted, while MIR4435-2HG knockdown inhibited the proliferation of chondrocytes. In contrast, MIR4435-2HG overexpression inhibited, while MIR4435-2HG knockdown promoted the apoptosis of chondrocytes. Conclusion MIR4435-2HG is downregulated in osteoarthritis and regulates chondrocyte cell proliferation and apoptosis. |
| Databáze: | OpenAIRE |
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