Evaluation of iterative reconstruction (OSEM) versus filtered back-projection for the assessment of myocardial glucose uptake and myocardial perfusion using dynamic PET

Autor: Mette Madsen, Hans Erik Bøtker, Torsten Toftegaard Nielsen, Ole Schmitz, Hanne Maare Søndergaard, Karin Boisen, Morten Bøttcher, Søren B. Hansen
Rok vydání: 2006
Předmět:
Male
Myocardium/metabolism
Image quality
Cardiology
Clinical settings
Iterative reconstruction
F-FDG PET
Sensitivity and Specificity
Myocardial blood flow
Fluorodeoxyglucose F18
Image Interpretation
Computer-Assisted
Perfusion/methods
Humans
Medicine
Radiology
Nuclear Medicine and imaging
Fluorodeoxyglucose F18/pharmacokinetics
medicine.diagnostic_test
Radon transform
business.industry
Myocardium
Image Interpretation
Computer-Assisted/methods
Reproducibility of Results
Heart
General Medicine
Middle Aged
Reconstruction quantification
Heart/diagnostic imaging
Positron-Emission Tomography/methods
Perfusion
Filtered backprojection
PET
Cardiac PET
Positron emission tomography
Positron-Emission Tomography
Radiopharmaceuticals/pharmacokinetics
Female
Radiopharmaceuticals
business
Nuclear medicine
Algorithms
Zdroj: Søndergaard, H M, Madsen, M M, Boisen, K, Bøttcher, M, Schmitz, O, Nielsen, T T, Bøtker, H E & Hansen, S B 2007, ' Evaluation of iterative reconstruction (OSEM) versus filtered back-projection for the assessment of myocardial glucose uptake and myocardial perfusion using dynamic PET ', European journal of nuclear medicine and molecular imaging, vol. 34, no. 3, pp. 320-329 . https://doi.org/10.1007/s00259-006-0198-z
Aarhus University
Søndergaard, H, Madsen, M M, Boisen, K, Bøttcher, M, Schmitz, O, Nielsen, T T, Bøtker, H E & Hansen, S B 2007, ' Evaluation of iterative reconstruction (OSEM) versus filtered back-projektion for the assessment of myocardial glucose uptake and myocardial perfusion using dynamic PET. ', Eur. J. Nucl. Med. Mol. Imaging, vol. 34, no. 3, pp. 320-9 .
Søndergaard, H M, Madsen, M M, Boisen, K, Bøttcher, M, Schmitz, O, Nielsen, T T, Bøtker, H E & Hansen, S B 2007, ' Evaluation of iterative reconstruction (OSEM) versus filtered back-projection for the assessment of myocardial glucose uptake and myocardial perfusion using dynamic PET ', European journal of nuclear medicine and molecular imaging, vol. 34, no. 3, pp. 320-9 . https://doi.org/10.1007/s00259-006-0198-z
ISSN: 1619-7089
1619-7070
DOI: 10.1007/s00259-006-0198-z
Popis: Purpose: Iterative reconstruction methods based on ordered-subset expectation maximisation (OSEM) has replaced filtered backprojection (FBP) in many clinical settings owing to the superior image quality. Whether OSEM is as accurate as FBP in quantitative positron emission tomography (PET) is uncertain. We compared the accuracy of OSEM and FBP for regional myocardial 18F-FDG uptake and 13NH3 perfusion measurements in cardiac PET. Methods: Ten healthy volunteers were studied. Five underwent dynamic 18F-FDG PET during hyperinsulinaemic-euglycaemic clamp, and five underwent 13NH3 perfusion measurement during rest and adenosine-induced hyperaemia. Images were reconstructed using FBP and OSEM ± an 8-mm Gaussian post-reconstruction filter. Results: Filtered and unfiltered images showed agreement between the reconstruction methods within ±2SD in Bland-Altman plots of K i values. The use of a Gaussian filter resulted in a systematic underestimation of K i in the filtered images of 11%. The mean deviation between the reconstruction methods for both unfiltered and filtered images was 1.3%. Agreement within ±2SD between the methods was demonstrated for perfusion rate constants up to 2.5 min-1, corresponding to a perfusion of 3.4 ml g-1 min-1. The mean deviation between the two methods for unfiltered data was 2.7%, and for filtered data, 5.3%. Conclusion: The 18F-FDG uptake rate constants showed excellent agreement between the two reconstruction methods. In the perfusion range up to 3.4 ml g-1 min-1, agreement between 13NH3 perfusion obtained with OSEM and FBP was acceptable. The use of OSEM for measurement of perfusion values higher than 3.4 ml g-1 min-1 requires further evaluation.
Databáze: OpenAIRE
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