Recent Management of Malignant Ovarian Germ Cell Tumors: A Study of 34 Cases
| Autor: | Bullangpoti S, Nathapong Israngura, Vasant Linasmita, Tangtrakul S, Sarikapan Wilailak, Srisupundit S |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.medical_treatment Dysgerminoma Humans Medicine Stage (cooking) Child Neoplasm Staging Retrospective Studies Ovarian Neoplasms Cisplatin Chemotherapy Radiotherapy business.industry Remission Induction Endodermal Sinus Tumor Teratoma Obstetrics and Gynecology PVB Regimen medicine.disease Endodermal sinus tumor Combined Modality Therapy Surgery Female Immature teratoma Germinoma Germ cell tumors business medicine.drug |
| Zdroj: | Journal of Obstetrics and Gynaecology Research. 25:315-320 |
| ISSN: | 1447-0756 1341-8076 |
| DOI: | 10.1111/j.1447-0756.1999.tb01169.x |
| Popis: | Objective: To review the outcome of the treatment in patients with malignant ovarian Germ cell tumors with respect to survival and surgical management at a single institution during 1990–1996. Methods: Thirty-four patients with malignant ovarian Germ cell tumors were studied retrospectively for their surgical management. Fourteen patients had pure dysgerminoma, 11 endodermal sinus tumor, 6 immature teratoma, and 3 mixed Germ cell tumors. Nine patients had stage IA, 8 stage IC, 2 stage IIC, 8 stage III, 3 stage IV, and 4 referred patients with recurrent diseases. Results: Nineteen patients underwent primary conservative surgery, 11 had primary nonconservative surgery. Twenty-two patients were treated with chemotherapy (BEP or EP or PVB regimen). Five patients with pure dysgerminoma received adjuvant radiotherapy. Persistent remission was achieved in 26 patients. Two patients (7.4%) had recurrence after remission. Seven patients had died of the diseases. Patients with complete clinical remission did not undergo second-look surgery. The overall survival was 78.8%, 100% for immature teratoma, 84.6% for pure dysgerminoma, 72.8% for endodermal sinus tumor, and 33.3% for mixed Germ cell tumors, with median follow-up time 31 (3–93) months. Conclusion: Patients with limited diseases regardless of histologic types can be safely managed by unilateral salpingo-oophorectomy followed by, if indicated, 3–4 courses of cisplatin-based chemotherapy. For advanced diseases, conservative surgery is advisable in patients with endodermal sinus tumor. |
| Databáze: | OpenAIRE |
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