Prognostic Significance of Subungual Anatomic Site in Acral Lentiginous Melanoma
| Autor: | Doina Ivan, Haider A. Mejbel, Ana M. Ciurea, Carlos A. Torres-Cabala, Jonathan L. Curry, Denái R. Milton, Phyu P. Aung, Victor G. Prieto, Adam I. Rubin, Wen-Jen Hwu, Priyadharsini Nagarajan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Time Factors Adolescent Databases Factual Biopsy Sentinel lymph node Anatomic Site Acral lentiginous melanoma Risk Assessment Pathology and Forensic Medicine Breslow Thickness 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Risk Factors Medicine Humans Child Melanoma Aged Retrospective Studies Aged 80 and over integumentary system business.industry Hazard ratio Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Dermatology Survival Rate Medical Laboratory Technology Nails 030220 oncology & carcinogenesis Cutaneous melanoma Melanocytes Female Risk of death business |
| Zdroj: | Archives of pathologylaboratory medicine. 145(8) |
| ISSN: | 1543-2165 |
| Popis: | Context.— Acral lentiginous melanoma is a rare and aggressive type of cutaneous melanoma that arises on the acral skin and the nail unit. The prognostic significance of subungual anatomic site in acral lentiginous melanoma is not established. Objective.— To assess the impact of subungual anatomic site on overall survival and disease-specific survival in acral lentiginous melanoma. Design.— Retrospective cohort analysis. Clinicopathologic characteristics of 627 primary acral lentiginous melanomas (45 [7%] subungual and 582 [93%] nonsubungual) were summarized, and the impact of these characteristics on overall survival and disease-specific survival was determined using univariate and multivariable analyses. Results.— No significant differences in clinicopathologic features were identified between the subungual and nonsubungual acral lentiginous melanomas. The 1-, 5-, and 10-year overall survival rates were 81%, 40%, and 28%, respectively, for subungual acral lentiginous melanoma and 94%, 59%, and 38%, respectively, for nonsubungual acral lentiginous melanoma (P = .04); risk of death was significantly higher for subungual tumors (hazard ratio [95% confidence interval] = 1.59 [1.02–2.50]; P = .04). The 1-, 5-, and 10-year disease-specific survival rates were 94%, 56%, and 48%, respectively, for subungual acral lentiginous melanoma versus 96%, 69%, and 55%, respectively, for nonsubungual acral lentiginous melanoma (P = .18). By multivariable analysis, independent poor prognostic factors included older age and ulceration for overall survival and greater Breslow thickness and sentinel lymph node positivity for overall survival and disease-specific survival. Subungual anatomic site was not an independent prognostic factor for overall or disease-specific survival. Conclusions.— Subungual anatomic site is not an independent prognostic factor for acral lentiginous melanoma. |
| Databáze: | OpenAIRE |
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