Prospective Therapeutic Applications of Platelet Extracellular Vesicles
| Autor: | Thierry Burnouf, Yu Wen Wu, Chantelle Blyth, Jancy Johnson, Gregor Lichtfuss, Hadi Goubran |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Blood Platelets
0301 basic medicine business.industry Regeneration (biology) Bioengineering 02 engineering and technology Extracellular vesicle Regenerative Medicine 021001 nanoscience & nanotechnology Extracellular vesicles Exosome Regenerative medicine Cell biology Extracellular Vesicles 03 medical and health sciences Drug Delivery Systems 030104 developmental biology Hemostasis Drug delivery Humans Medicine Platelet 0210 nano-technology business Biotechnology |
| Zdroj: | Trends in Biotechnology. 39:598-612 |
| ISSN: | 0167-7799 |
| DOI: | 10.1016/j.tibtech.2020.10.004 |
| Popis: | There is much interest in the use of extracellular vesicles (EVs) as a subcellular therapy for regenerative medicine and drug delivery. Blood-borne platelets represent a source of therapeutic EVs that is so far largely unexplored. Advantages of platelets as a cellular source of EVs include their established clinical value, regulated collection procedures, availability in a concentrated form, propensity to generate EVs, and unique composition and tissue-targeting capacity. This review analyzes the unique potential of platelet-derived (p-) EVs as therapeutic modalities and presents their inherent translational advantages for hemostasis, for regenerative medicine, and as drug-delivery vehicles. |
| Databáze: | OpenAIRE |
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