The relationship between plasma GIP and GLP-1 levels in individuals with normal and impaired glucose tolerance
Autor: | Michael A. Nauck, Jessica A Marathe, Liza K. Phillips, Christopher K. Rayner, Chinmay S. Marathe, Tongzhi Wu, Hung Pham, Karen L. Jones, Laurence G. Trahair, Lian Huynh, Michael Horowitz |
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Rok vydání: | 2019 |
Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Serum insulin Incretin Gastric Inhibitory Polypeptide Type 2 diabetes Impaired glucose tolerance Endocrinology Glucagon-Like Peptide 1 Internal medicine Diabetes mellitus Glucose Intolerance Internal Medicine medicine Humans Insulin Aged business.industry Weak relationship Healthy subjects General Medicine Glucose Tolerance Test medicine.disease Small intestine medicine.anatomical_structure Diabetes Mellitus Type 2 Case-Control Studies Female business hormones hormone substitutes and hormone antagonists |
Zdroj: | Acta Diabetologica. 57:583-587 |
ISSN: | 1432-5233 0940-5429 |
Popis: | Glucose-dependent insulinotropic polypeptide (GIP) is released primarily from the proximal small intestine and glucagon-like peptide-1 (GLP-1) from the more distal small intestine and colon. Their relative importance to the incretin effect in health has been contentious in the past, although it now appears that GIP has the dominant role. It is uncertain whether there is a relationship between GIP and GLP-1 secretion. We aimed to evaluate the relationship between plasma GIP and GLP-1 responses to a 75-g oral glucose load in individuals with normal (NGT) and impaired glucose tolerance (IGT). One hundred healthy subjects had measurements of blood glucose, serum insulin, plasma GIP and GLP-1 concentrations for 240 min after a 300 mL drink containing 75 g glucose. Fifty had NGT and 41 IGT; 9 had type 2 diabetes and were excluded from analysis. In both groups, there were increases in plasma GIP and GLP-1 following the glucose drink, with no difference in the magnitude of the responses between t = 0–240 min. There was a weak relationship between the iAUC0–240 min for GIP and GLP-1 in the combined (r = 0.23, P = 0.015) and in the IGT (r = 0.34, P = 0.01), but not in the NGT (r = 0.15, P = 0.14) group. There is a weak relationship between oral glucose-induced GIP and GLP-1 secretions in non-diabetic subjects. |
Databáze: | OpenAIRE |
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