Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model
| Autor: | Manabu Kitano, Toshiaki Minami, Sayuri Matsunami, Seiji Ito, Denan Jin, Atsushi Fujiwara, Kenta Nakao, Nobuyasu Komasawa, Shinji Takai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Article Subject business.industry Bone cancer Yokukansan Bone metastasis lcsh:Other systems of medicine Matrix metalloproteinase Pharmacology medicine.disease Bone tissue lcsh:RZ201-999 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Complementary and alternative medicine Oral administration Neuropathic pain Medicine business Cancer pain 030217 neurology & neurosurgery Research Article 030304 developmental biology |
| Zdroj: | Evidence-Based Complementary and Alternative Medicine, Vol 2019 (2019) Evidence-based Complementary and Alternative Medicine : eCAM |
| ISSN: | 1741-4288 |
| Popis: | Bone cancer pain control is difficult because it includes various characteristics of pain such as nociceptic and neuropathic pain. In this study, we investigated the effect of yokukansan (YKS), one of the traditional Japanese herbal medicines, on cancer pain in mouse bone metastasis model. Oral administration of YKS significantly alleviated pain behavior measured by quantitative body weight bearing. Furthermore, the pain behavior was also significantly alleviated by intrathecal and intraperitoneal administration of matrix metalloproteinase- (MMP-) 9 inhibitor, but not of MMP-2 inhibitor. MMP-9 expression was significantly elevated in the bone tissue on day 3 after carcinoma cell injection and in the ipsilateral spinal cord on day 7, which was suppressed by YKS administration. Taken together, these results suggest that YKS alleviates cancer pain via suppressing MMP-9 expression in bone metastasis model in mice. |
| Databáze: | OpenAIRE |
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