A scoring model for predicting prognosis of patients with severe fever with thrombocytopenia syndrome
| Autor: | Chao Wu, Biyun Xu, Yang Li, Yong Liu, Weihua Wu, Xiaomin Yan, Peixin Song, Yingying Hao, Guiyang Wang, Yuxin Chen, Zhaoping Zhang, Juan Xia, Yali Xiong, Bei Jia, Rui Huang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Phlebovirus Fevers Aminotransferases Disease Pathology and Laboratory Medicine Biochemistry 0302 clinical medicine Medicine and Health Sciences 030212 general & internal medicine biology lcsh:Public aspects of medicine Mortality rate Hematology Middle Aged Viral Load Prognosis Hospitals Clinical Laboratory Sciences Enzymes Clinical Laboratories Infectious Diseases Creatinine Female Viral load Research Article Adult Poor prognosis medicine.medical_specialty China lcsh:Arctic medicine. Tropical medicine lcsh:RC955-962 Death Rates 030106 microbiology Bunyaviridae Infections Sensitivity and Specificity Microbiology SFTS bunyavirus Decision Support Techniques 03 medical and health sciences Signs and Symptoms Population Metrics Diagnostic Medicine Transferases Virology medicine Humans Intensive care medicine Aged Population Biology business.industry Public Health Environmental and Occupational Health Biology and Life Sciences Proteins lcsh:RA1-1270 biology.organism_classification medicine.disease Thrombocytopenia Severe fever with thrombocytopenia syndrome Infectious disease (medical specialty) Enzymology business Biomarkers Viral Transmission and Infection |
| Zdroj: | PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005909 (2017) |
| ISSN: | 1935-2735 |
| Popis: | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging epidemic infectious disease caused by the SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate of 12.7% to 32.6%. Currently, the disease has been reported in mainland China, Japan, Korea, and the United States. At present, there is no specific antiviral therapy for SFTSV infection. Considering the higher mortality rate and rapid clinical progress of SFTS, supporting the appropriate treatment in time to SFTS patients is critical. Therefore, it is very important for clinicians to predict these SFTS cases who are more likely to have a poor prognosis or even more likely to decease. In the present study, we established a simple and feasible model for assessing the severity and predicting the prognosis of SFTS patients with high sensitivity and specificity. This model may aid the physicians to immediately initiate prompt treatment to block the rapid development of the illness and reduce the fatality of SFTS patients. Author summary Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel SFTS bunyavirus (SFTSV) with an estimated high case-fatality rate. However, there is no specific antiviral therapy for SFTSV infection. Symptomatic treatment and supportive therapy are the most essential part of case management. It is very important for clinicians to identify critical patients at admission. In this study, we established a simple and feasible scoring system for assessing the severity and predicting the prognosis of SFTS patients with objective parameters. This model may help the physicians to perform intervention measures in advance, control the disease progression and improve the prognosis. |
| Databáze: | OpenAIRE |
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