Salvage endoscopic submucosal dissection for recurrent esophageal squamous-cell carcinoma after definitive chemoradiotherapy
| Autor: | Naoki Ishii, Koyu Suzuki, Yoshiyuki Fujita |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Standard treatment Gastroenterology Recurrent Esophageal Squamous Cell Carcinoma General Medicine Esophageal cancer medicine.disease Surgery Endoscopy medicine.anatomical_structure medicine Carcinoma Esophagus Unresectable Esophageal Carcinoma business Chemoradiotherapy |
| Zdroj: | Clinical journal of gastroenterology. 4(2) |
| ISSN: | 1865-7257 |
| Popis: | Although concurrent definitive chemoradiotherapy (CRT) is considered a standard treatment for unresectable esophageal carcinoma, CRT is associated with local failure (40–50%), and further interventions are needed in these cases. However, morbidity and mortality rates remain high among patients undergoing salvage esophagectomy for recurrent tumors. Here, we report a rare experience of salvage endoscopic submucosal dissection (ESD) for recurrent esophageal squamous-cell carcinoma (SCC) after definitive CRT. A 55-year-old male was diagnosed with unresectable advanced mid-thoracic esophageal SCC with lymph node metastases involving the trachea. After definitive CRT with cis-diamminedichloroplatinum (CDDP)/5-fluorouracil (5-FU) and 60 Gy irradiation was performed, complete response was obtained. However, a recurrent esophageal SCC was detected in the mid-thoracic esophagus on endoscopy performed 6 months after CRT. The tumor was resected en bloc using ESD without any complications. There was no recurrence for 4 months after ESD. Salvage ESD may be a safe and effective treatment for recurrent esophageal SCC after CRT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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