Fabrication and Characterization of Porous Tubular Silk Fibroin Scaffolds
| Autor: | Li Tian, Lin Liu, Juming Yao, Liangjun Zhu, Xin Gao, Haiping Zhang, Sijia Min |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pore size
Materials science Fabrication Surface Properties Silk Biomedical Engineering Biophysics Fibroin Biocompatible Materials Bioengineering Biomaterials Mice Ultimate tensile strength Animals Composite material Porosity Aqueous solution Tissue Engineering Tissue Scaffolds Epoxy Resins technology industry and agriculture Biomaterial Characterization (materials science) Microscopy Electron Scanning Fibroins |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 20:1961-1974 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1163/156856208x396056 |
| Popis: | Silk fibroin (SF) has been one of promising resources of biotechnology and biomedical materials due to its unique properties. Here, different sizes of porous tubular scaffolds were fabricated from a SF aqueous solution with the addition of poly(ethylene glycol diglycidyl ether) (PGDE). The scaffolds were generally flexible and transparent at the wet state with a pore size of 81-128 mum and porosity of 90-96%, depending on the concentrations of SF and PGDE. The mechanical properties measurement showed that the tubular SF scaffolds had satisfying tensile and compression properties, especially the excellent deformation-recovery ability. FT-IR spectra indicated that the SF in the tubular scaffolds was in a beta-sheet structure, and no PGDE characteristic band was observed, suggesting that the PGDE could be removed from the scaffolds by soaking in deionized water. The cell compatibility of scaffolds was evaluated, and no obvious cytotoxicity to mouse L-929 fibroblasts was detected. |
| Databáze: | OpenAIRE |
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