Development of imaging biomarker for esophageal cancer using intravoxel incoherent motion MRI
| Autor: | Tetsuro Isozaki, Ryoma Urahama, Gaku Ohira, Yuko Ikeda, Koichi Hayano, Kentaro Murakami, Masaya Uesato, Ryoya Mizumachi, Atsushi Hirata, Shunsuke Imanishi, Takeshi Toyozumi, Toru Tochigi, Hisahiro Matsubara, Yoshihiro Kurata |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Esophageal Neoplasms Imaging biomarker 03 medical and health sciences 0302 clinical medicine medicine Humans Effective diffusion coefficient Stage (cooking) Intravoxel incoherent motion Aged Retrospective Studies business.industry Gastroenterology Esophageal cancer medicine.disease Magnetic Resonance Imaging Primary tumor 030220 oncology & carcinogenesis T-stage Biomarker (medicine) Female 030211 gastroenterology & hepatology Esophageal Squamous Cell Carcinoma business Nuclear medicine Biomarkers |
| Zdroj: | Esophagus. 18:844-850 |
| ISSN: | 1612-9067 1612-9059 |
| Popis: | Intravoxel incoherent motion MRI (IVIM-MRI) can quantify micro-perfusion at the capillary level in the tissue. The purpose of this study is to measure tumor perfusion using IVIM-MRI, and evaluate its value as a biomarker to predict prognosis in esophageal squamous cell carcinoma (ESCC) patients. 109 ESCC patients (93 men and 16 women; median age: 72) who underwent IVIM-MRI prior to treatment between February 2018 and August 2020 were retrospectively investigated. Both mean apparent diffusion coefficient (ADC) value and mean perfusion-related parameter (PP) value of the primary tumor were measured using three b values of 0, 400, and 1000 s/mm2 based on the IVIM model. We analyzed associations of these parameters with clinical stage and disease-specific survival (DSS). Lower ADC and PP values of the tumor were significantly associated with the higher clinical T stage (p |
| Databáze: | OpenAIRE |
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