Cholesterol and ceramide: An unlikely pair
| Autor: | García Arribas, Aritz B., Alonso, Alicia, Goñi, Félix M. |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), European Commission, Eusko Jaurlaritza, Fundación Biofísica Bizkaia |
| Rok vydání: | 2022 |
| Předmět: | |
| DOI: | 10.1016/b978-0-323-85857-1.00017-1 |
| Popis: | Cholesterol (Chol) has been commonly considered as a structural component in lipid membranes, with the capacity to induce formation of liquid-ordered platforms that might in turn have a decisive effect on membrane trafficking and protein clustering. Meanwhile, sphingolipids have appeared as important pieces of the “membrane puzzle,” with many of them playing bioactive roles in a variety of cellular processes. Among sphingolipids, some of them (e.g., sphingomyelins, SM) appear to exhibit a preferential interaction with Chol, while others (such as ceramides, Cer) have been described to compete with Chol for the same interaction sites, mostly in the SM amide group, due to the high hydrophobicity of both molecules. However, publications in the last decade have demonstrated that Chol and Cer may not always displace each other; rather, they can interact in a mutually stabilizing fashion, particularly in the presence of SM. More importantly, experiments have shown that this interaction may also occur in predominantly fluid (but heterogeneous) membranes. Furthermore, while the early experiments to probe this interaction explored the effects of C16:0 sphingolipids, newer reports have shown that Chol-Cer interactions are also possible in the presence of C24:0 and/or C24:1 sphingolipids, which are (together with C16:0) among the most abundant sphingolipid species occurring in natural membranes. In this manuscript, we explore the latest reports on this issue, which are mainly centered on different scenarios where Chol-Cer interactions may appear, and the putative relevance of such interactions on membrane functionality. This work was supported in part by the Spanish Ministerio de Ciencia e Innovación (MCI), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (grant No. PGC2018-099857-B-I00), by the Eusko Jaurlaritza (Grants No. IT1264-19, IT1196-19, and IT1270-19), by the Fundación Biofísica Bizkaia, and by the Basque Excellence Research Centre (BERC) program of the Basque Government. |
| Databáze: | OpenAIRE |
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