Pentraxin 3 and atherosclerosis among type 2 diabetic patients
Autor: | Andrzej Tomasik, Hanna Kwiendacz, Katarzyna Nabrdalik, Władysław Grzeszczak, Wojciech Bartman, Janusz Gumprecht, Artur Chodkowski, Michał Kukla, Tomasz Sawczyn |
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Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
Cardiac function curve medicine.medical_specialty diabetes mellitus type 2 QH301-705.5 Carotid arteries 030204 cardiovascular system & hematology Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine macrovascular complications carotid arteries Internal medicine medicine pentraxin 3 Biology (General) Pentraxin-3 intracranial arteries General Immunology and Microbiology General Neuroscience 030104 developmental biology Cardiology atherosclerosis cardiac function General Agricultural and Biological Sciences |
Zdroj: | Open Life Sciences, Vol 12, Iss 1, Pp 92-98 (2017) |
ISSN: | 2391-5412 |
Popis: | Type 2 diabetes is contemporarily a major social and epidemiological problem and among others is a strong risk factor for cardiovascular diseases. Pentraxin 3, a potential early biomarker of atherosclerosis, is an acute-phase reactant produced by the peripheral tissues where the inflammation takes place. In this study we examined a group of patients with type 2 diabetes with and without cardiovascular complications compared to persons with normal glucose tolerance (patients with cardiovascular complications and healthy volunteers). Plasma pentraxin 3 concentration as well as some basic biochemical blood analysis were performed. Moreover, transcranial and carotid Doppler ultrasound examination as well as transthoracic echocardiography were performed. It turned out that there was an association of plasma pentraxin 3 concentration and carotid atherosclerosis found in the control group of patients with cardiovascular complications but with normal glucose tolerance. In the group of patients with type 2 diabetes and cardiovascular complications we have found an association of plasma pentraxin 3 concentration with diastolic left ventricular dysfunction. Additionally, in the group of patients with type 2 diabetes without cardiovascular disease plasma pentraxin 3 concentration was associated with elevated urinary albumin creatinine ratio. Further studies, on a larger group of patients, are required to confirm these observations. |
Databáze: | OpenAIRE |
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