In Silico Protein-Protein Interaction of Pterois volitans Venom with Cancer Inducers of Helicobacter pylori
| Autor: | Karthikeyan Ramalingam, Sneha Unnikrishnan, Irfan Navabshan, Guru Nivetha Ravi |
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| Rok vydání: | 2021 |
| Předmět: |
Fish Proteins
Virulence Factors In silico Virulence Bioengineering Venom Applied Microbiology and Biotechnology Biochemistry Microbiology Protein–protein interaction chemistry.chemical_compound Bacterial Proteins Fish Venoms Stomach Neoplasms medicine Animals Humans Molecular Biology Helicobacter pylori biology Cancer General Medicine Venom Protein medicine.disease biology.organism_classification Bioactive compound Perciformes Molecular Docking Simulation chemistry Biotechnology |
| Zdroj: | Applied Biochemistry and Biotechnology. 194:354-367 |
| ISSN: | 1559-0291 0273-2289 |
| DOI: | 10.1007/s12010-021-03763-x |
| Popis: | Gastric cancer is a pathological condition induced by the bacteria Helicobacter pylori. Targeting the key virulence factors of H. pylori causing gastric cancer is a promising method for treating gastric cancer. Recently, research has been focused on analyzing the adrenergic, cholinergic, and anti-cancer properties of their venom proteins. Testing the anti-cancer activity of the lethal proteins in the venom of P. volitans provides a bioactive compound for cancer treatment. Still, it is also helpful to eliminate the ecological imbalance caused by these fish in the marine environment. This study focuses on an in silico approach using Z-dock to analyze the bioactive prospective of the venom proteins of P. volitans against the essential virulence proteins of H. pylori responsible for inducing cancer. Our in silico docking study using a computational model of the venom proteins and H. pylori proteins has displayed the possible interactions between these proteins. The results revealed that P. volitans hyaluronidase and PV toxin's venom proteins effectively interact with H. pylori proteins Cag A, Cag L, GGT, Cag D, and urease that may be promising proteins in cancer therapy. |
| Databáze: | OpenAIRE |
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