Tyrosinase activity in human skin. Influence of race and age in newborns
| Autor: | I G Ances, S H Pomerantz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Tyrosinase Black People Human skin Catalysis White People Hydroxylation chemistry.chemical_compound Internal medicine medicine Humans Tyrosinase activity Tyrosine Catechol oxidase Skin biology Age Factors Infant Newborn General Medicine Hydrogen Peroxide Catalase Infant newborn Enzyme assay Kinetics Endocrinology Biochemistry chemistry biology.protein Catechol Oxidase Research Article |
| Popis: | Tyrosinase has been measured in homogenates of foreskins from newborn babies. The tyrosine hydroxylation reaction is dependent upon 3,4-dihydroxyphenylalanine as a cosubstrate, and the Km for tyrosine is 0.15 mM, similar to the value observed for other mammalian tyrosinases. The mean enzyme activity for black babies (n = 169) is about two and one-fourth times that for white babies (n = 82). For white babies there is a significant correlation between age at circumcision and tyrosinase activity. For black babies this correlation becomes significant when four individuals with extremely high tyrosinase activities are omitted from the series. |
| Databáze: | OpenAIRE |
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