Systemic Oxidative Stress to Nucleic Acids Is Unaltered Following Radioiodine Therapy of Patients with Benign Nodular Goiter
| Autor: | Kasper Broedbaek, Steen Joop Bonnema, Allan Weimann, Elisabeth S. Stovgaard, Søren Fast, Laszlo Hegedüs, Henrik E. Poulsen, Jon Trærup Andersen, Peter Grupe |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Translational Thyroidology / Original Paper Goiter business.industry 8 oxo 7 8 dihydro 2 deoxyguanosine Endocrinology Diabetes and Metabolism Thyroid Radioiodine therapy medicine.disease medicine.disease_cause medicine.anatomical_structure Endocrinology Internal medicine Nucleic acid Medicine Radioactive iodine Whole body business Oxidative stress |
| Zdroj: | Bonnema, S J, Stovgaard, E S, Fast, S, Broedbaek, K, Andersen, J T, Weimann, A, Grupe, P, Hegedüs, L & Poulsen, H E 2015, ' Systemic oxidative stress to nucleic acids is unaltered following radioiodine therapy of patients with benign nodular goiter ', European Thyroid Journal, vol. 4, no. 1, pp. 20-25 . https://doi.org/10.1159/000371883 |
| DOI: | 10.1159/000371883 |
| Popis: | BACKGROUND: Little is known about the whole body oxidative stress burden following radioactive iodine ((131)I) therapy of thyroid diseases.METHODS: We studied 17 patients with benign nodular goiter treated with (131)I therapy. The targeted thyroid dose was 50 Gy in 11 patients pretreated with 0.1 mg of recombinant human TSH (rhTSH). In 6 patients, the applied thyroid dose was 100 Gy without rhTSH prestimulation. Well-established biomarkers of oxidative stress to RNA (8-oxo-7,8-dihydroguanosine; 8-oxoGuo) and DNA (8-oxo-7,8-dihydro-2'-deoxyguanosine; 8-oxodG) were measured in freshly voided morning urine (normalized against the creatinine concentration) at baseline, and 7 and 21 days after rhTSH (not followed by (131)I), and 7 and 21 days after (131)I therapy, respectively.RESULTS: The baseline urinary excretions of 8-oxoGuo and 8-oxodG were 2.20 ± 0.84 and 1.63 ± 0.70 nmol/mmol creatinine, respectively. We found no significant changes in the excretion of any of the metabolites, neither after rhTSH stimulation alone nor after (131)I therapy. Also, no significant differences were found between the rhTSH group (low dose, median (131)I: 152 MBq) and the non-rhTSH group (high dose, median (131)I: 419 MBq; 8-oxoGuo: p = 0.66, 8-oxodG: p = 0.71).CONCLUSION: Systemic oxidative stress, as detected by nucleic acids metabolites in the urine, is not increased after thyroid stimulation with 0.1 mg of rhTSH, or after (131)I therapy. Our method cannot quantify the oxidative stress induced locally in the thyroid gland, but the study supports that (131)I therapy of benign nodular goiter carries no or only a minute risk of developing subsequent malignancies. It remains to be explored whether our findings also apply to hyperthyroid disorders. |
| Databáze: | OpenAIRE |
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