Looking toward predicting functional recovery in disorders of consciousness: can sensorimotor integration help us?
| Autor: | Antonino Leo, Paola Lauria, Provvidenza Tomasello, Alfredo Manuli, Rocco Salvatore Calabrò, Antonino Naro, Bruno Galletti, Alessia Bramanti, Veronica Andronaco, Luana Billeri |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male genetic structures Neuroscience (miscellaneous) Glasgow Outcome Scale Neural Inhibition disorders of consciousness MCS prognosis Sensorimotor integration UWS Aged Biomarkers Brain Injuries Consciousness Disorders Female Follow-Up Studies Humans Longitudinal Studies Middle Aged Persistent Vegetative State Prognosis Recovery of Function 050105 experimental psychology 03 medical and health sciences 0302 clinical medicine Afferent Developmental and Educational Psychology Medicine 0501 psychology and cognitive sciences Persistent vegetative state business.industry Neurology (clinical) 05 social sciences Follow up studies Functional recovery medicine.disease business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Injury. 33:364-369 |
| ISSN: | 1362-301X 0269-9052 |
| DOI: | 10.1080/02699052.2018.1553309 |
| Popis: | Only a few objective prognostic markers are available for patients with disorders of consciousness (DoC). We assessed whether the magnitude of short-latency afferent inhibition (SAI) might be a useful predictor of responsiveness recovery and functional outcome in patients with DoC.We enrolled 40 patients with prolonged Minimally Conscious State (MCS) and Unresponsive Wakefulness Syndrome (UWS) in a longitudinal, observational study.Clinical features (including Coma Recovery Scale-Revised, CRS-R, and Glasgow Outcome Scale, GOS) and SAI were collected at the study entry and after 18 months from study inclusion, to assess a correlation between SAI and the clinical outcome.At the follow-up, 19 patients remained in their baseline condition, whereas 7 UWS evolved into MCS or emerged-from-MCS (EMCS), eight MCS evolved into EMCS, and two MCS- evolved into MCS+. Two UWS and one MCS+ died for cardiopulmonary complications. The patients who showed the highest GOS, the highest CRS-R and the lowest SAI strength at study entry, improved at the follow-up.Our findings suggest that an objective and simple neurophysiologic measure as SAI strength could provide useful information to predict the outcome and the behavioral responsiveness of patients with DoC. |
| Databáze: | OpenAIRE |
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