Disease Characteristics and the Burden of Joint and Skin Involvement Amongst People With Psoriatic Arthritis: A Population Survey

Autor: Wolf-Henning Boehncke, Julie Birt, L Steve Lobosco, William Tillett, Elizabeth Holdsworth, Gary Milligan, Joseph F. Merola, Matthew M. Hufford, Nicola Booth, Diamant Thaçi
Rok vydání: 2020
Předmět:
Zdroj: Rheumatology and Therapy, Vol 7, Iss 3, Pp 617-637 (2020)
Rheumatology and Therapy, Vol. 7, No 3 (2020) pp. 617-637
Rheumatology and Therapy
ISSN: 2198-6584
2198-6576
DOI: 10.1007/s40744-020-00221-8
Popis: Introduction Psoriatic arthritis (PsA) is a chronic, systemic, inflammatory disease where disease burden and quality of life (QoL) are affected by both joint and skin manifestations. Methods Patient and physician reported data were collected about 3200 patients in a cross-sectional survey of patients from nine countries. Patient-reported outcomes (PROs) included perceptions of symptom importance, EuroQol questionnaire (EQ-5D), Psoriatic Arthritis Impact of Disease (PsAID12), and Work Productivity and Activity Impairment (WPAI) Index. Outcomes were compared in patients with ‘joint-only’ and ‘joint and skin’ disease symptoms. Results Of the 3200 patients, 2703 had complete information for ‘joint-only’ or ‘joint and skin’ involvement and were included in the analysis. Patients had a mean age of 49.2 years, 45.2% were female, and 64.5% had ‘joint and skin’ involvement. Patients with ‘joint and skin’ involvement had higher mean tender and swollen joint counts (5.2 and 4.8) than patients who were ‘joint-only’ (2.0 and 1.5). Significantly more patients with active ‘joint and skin’ symptoms experienced a flare (currently or within the last 12 months) compared with ‘joint-only’ patients (34.9 vs. 23.2%, p
Databáze: OpenAIRE
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