Long-Acting GLP-1 Receptor Agonist Exenatide Influence on the Autonomic Cardiac Sympatho-Vagal Balance
| Autor: | Karl Thomaseth, Maddalena Trombetta, F. Bellavere, Marco Dauriz, Francesca De Santi, Enzo Bonora, Riccardo Rigolon, Lorenza Santi, Vittorio Cacciatori, Isabella Pichiri, Giacomo Zoppini, Giovanni Targher |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Diabetes Pancreatic and Gastrointestinal Hormones GLP-1 receptor agonist Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Internal medicine Heart rate medicine Glucagon-like peptide 1 receptor Clinical Research Articles power spectral analysis business.industry autonomic nervous system GLP-1 receptor agonist power spectral analysis autonomic nervous system medicine.disease Autonomic nervous system Endocrinology Blood pressure Ambulatory business Exenatide medicine.drug |
| Zdroj: | Journal of the Endocrine Society 2 (2018): 53–62. doi:10.1210/js.2017-00300 info:cnr-pdr/source/autori:Cacciatori, Vittorio; Zoppini, Giacomo; Bellavere, Federico; Rigolon, Riccardo; Thomaseth, Karl; Pichiri, Isabella; Trombetta, Maddalena; Dauriz, Marco; De Santi, Francesca; Targher, Giovanni; Santi, Lorenza; Bonora, Enzo/titolo:Long-Acting GLP-1 Receptor Agonist Exenatide Influence on the Autonomic Cardiac Sympatho-Vagal Balance/doi:10.1210%2Fjs.2017-00300/rivista:Journal of the Endocrine Society/anno:2018/pagina_da:53/pagina_a:62/intervallo_pagine:53–62/volume:2 Journal of the Endocrine Society |
| Popis: | Long-acting glucagon-like peptide 1 receptor agonists are increasingly used to treat type 2 diabetes. An increase of heart rate (HR) has been observed with their use. To elucidate the role of the cardiac sympatho-vagal balance as a possible mediator of the reported increase in HR, we performed power spectral analysis of HR variability (HRV) in patients receiving exenatide extended-release (ER). Twenty-eight ambulatory patients with type 2 diabetes underwent evaluation at initiation of exenatide-ER and thereafter at 3 and at 6 months. To obtain spectral analyses of HRV, a computerized acquisition of 10 minutes of RR electrocardiogram intervals (mean values of ~700 RR intervals) were recorded both in lying and in standing positions. All patients showed a substantial increase of HR both in lying and in standing positions. Systolic blood pressure, body weight, and glycated hemoglobin A1c significantly decreased both at 3 and 6 months compared with basal levels. The low-frequency/high-frequency ratio varied from 3.05 ± 0.4 to 1.64 ± 0.2 (P < 0.001) after 3 months and to 1.57 ± 0.3 (P < 0.001) after 6 months in a lying position and from 4.56 ± 0.8 to 2.24 ± 0.3 (P < 0.001) after 3 months and to 2.38 ± 0.4 (P < 0.001) after 6 months in a standing position compared with basal values, respectively. HR variations, induced by exenatide-ER treatment, do not appear to be related to sympathetic autonomic tone. Of note, we observed a relative increase of vagal influence on the heart. Sympatho-vagal balance was evaluated on diabetics after treatment with long-acting GLP-1 agonist. The major finding is a “shifting” of sympatho-vagal balance with a reduced LF/HF ratio. |
| Databáze: | OpenAIRE |
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