Depression Severity as a Risk Factor of Sarcopenic Obesity in Morbidly Obese Patients

Autor: Céline Lambert, Clément Lahaye, C. Palmier-Forestier, M. Pouget, V. Venant, N. Farigon, Bruno Pereira, E. Gentes, Carla Domingues-Faria, J. Debarges, Yves Boirie, M. Miolanne
Přispěvatelé: Nutrition clinique, Centre Hospitalier Universitaire Gabriel Montpied, Biostatistiques, Danone Research, Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Physical disability
muscle
030309 nutrition & dietetics
Population
Medicine (miscellaneous)
macromolecular substances
sarcopenia
03 medical and health sciences
Grip strength
0302 clinical medicine
Risk Factors
Internal medicine
mental disorders
Prevalence
Humans
Medicine
Sarcopenic obesity
Muscle Strength
Obesity
030212 general & internal medicine
Risk factor
education
Depression (differential diagnoses)
0303 health sciences
education.field_of_study
Nutrition and Dietetics
business.industry
musculoskeletal
neural
and ocular physiology
[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology
medicine.disease
mobility
Obesity
Morbid
3. Good health
nervous system
Sarcopenia
depression
Female
Geriatrics and Gerontology
business
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Journal of Nutrition, Health and Aging
Journal of Nutrition, Health and Aging, Springer Verlag (Germany), 2019, 23 (8), pp.761-767. ⟨10.1007/s12603-019-1218-6⟩
Journal of Nutrition, Health & Aging
Journal of Nutrition, Health & Aging, 2019, 23 (8), pp.761-767. ⟨10.1007/s12603-019-1218-6⟩
ISSN: 1760-4788
1279-7707
DOI: 10.1007/s12603-019-1218-6
Popis: Etiopathogenic factors of physical disability in obesity are numerous, underestimated and not sought in the non-geriatric population. Amongst these factors, depression may favor the development of sarcopenic obesity by reducing strength and physical performance even in the absence of overt muscle loss. Objectives and participants: To study the link between depression status and muscle functional disorders (dynapenia) in a population of adult subjects with severe and morbid obesity.Patients were assessed for body composition, grip strength, the Short Physical Performances Battery test (SPPB), for depression according to the Beck II score as well as for metabolic parameters through biological tests.In 373 obese subjects (mean age 44 ± 13y and BMI 43 ± 6 kg/m²), the prevalence of depression was 53% with 18% having mild depression, 18% moderate depression and 16% severe depression. Depression was significantly related to dynapenia: 62% of dynapenic (D) patients suffered from depression compared to 50% of non-dynapenic (ND) patients (p = 0.036). The Beck questionnaire score for D patients was 20 ± 13 and 15 ± 10 for ND patients (p = 0.001). The depression intensity was significantly correlated with dynapenia with D patients having a higher severe depression degree than ND patients (30% versus 11%; p0.0001). Fat-free to fat mass ratio was also significantly correlated with dynapenia (p = 0.01). In multivariate analysis, the presence of depression was twice as likely to be associated with dynapenia.Depression is associated with a reduction of muscle function in severe obesity in relation to its severity and to changes in fat to fat-free mass, suggesting that screening and prevention of sarcopenic obesity should be considered in adult obese patients with depression.
Databáze: OpenAIRE
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