Prospective randomised study comparing tacrolimus (Prograf) and cyclosporin (Neoral) as primary immunosuppression in cadaveric renal transplants at a single institution: interim report of the first 80 cases

Autor: V. Balaji, R. Moore, R. Lord, K Ostrowski, Gareth Morris-Stiff, C. Darby, W. A. Jurewicz
Rok vydání: 1998
Předmět:
Zdroj: Transplant International. 11:S334-S336
ISSN: 1432-2277
0934-0874
DOI: 10.1007/s001470050492
Popis: As part of an ongoing study, 80 patients undergoing cadaveric renal transplantation were randomised to receive either Prograf [PTT (patients receiving Prograf); n = 40]- or Neoral [NTT (patients receiving Neoral); n = 40]-based immunosuppression as part of a triple therapy regimen. Prograf was commenced at a dose of 0.2 mg/kg per day and Neoral at 8 mg/kg per day. Both groups received identical azathioprine and corticosteroid regimens. Trough levels for Prograf were maintained between 5 and 15 ng/ml and for Neoral between 100 and 200 ng/ml. During the 3-month follow up 40 % of PTT and 33 % of NTT experienced biopsy-proven acute rejection. In each group 81 % of rejection episodes were classified as either borderline or grade 1. The median 3-month serum creatinine levels were 128 μmol/l and 135 μmol/l, respectively, for PTT and NTT. Six grafts were lost in the NTT group including three deaths with functioning grafts whilst none were lost in the PTT group (χ 2, P < 0.02). The prevalence of other complications was similar for the two groups. We conclude that Prograf represents an effective and safe therapy as a primary immunosuppressive agent following cadaveric renal transplantation and appears to have a similar side-effect profile to Neoral.
Databáze: OpenAIRE
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