A novel approach to paraneoplastic intestinal pseudo-obstruction
Autor: | Ambuga Badari, David Crossland, Deborah Farolino, Eiad Nasser, Shahid Mehboob |
---|---|
Rok vydání: | 2011 |
Předmět: |
Male
Nervous system Intestinal pseudo-obstruction medicine.medical_specialty Lung Neoplasms Cyclophosphamide Encephalomyelitis Gastroenterology Antibodies Monoclonal Murine-Derived Quality of life Internal medicine Antineoplastic Combined Chemotherapy Protocols Humans Paraneoplastic Polyneuropathy Medicine business.industry Intestinal Pseudo-Obstruction Limbic encephalitis Cancer Middle Aged medicine.disease Small Cell Lung Carcinoma Surgery Treatment Outcome medicine.anatomical_structure Oncology Quality of Life Rituximab business medicine.drug |
Zdroj: | Supportive Care in Cancer. 20:425-428 |
ISSN: | 1433-7339 0941-4355 |
DOI: | 10.1007/s00520-011-1305-7 |
Popis: | Paraneoplastic neurologic syndromes (PNS) are uncommon, affecting fewer than 1 in 10,000 patients with cancer. PNS, while rare, can cause significant morbidity and impose enormous socio-economic costs, besides severely affecting quality of life. PNS can involve any part of the nervous system and can present as limbic encephalitis, subacute cerebellar ataxias, opsoclonus-myoclonus, retinopathies, chronic intestinal pseudo-obstruction (CIPO), sensory neuronopathy, Lambert-Eaton myasthenic syndrome, stiff-person syndrome, and encephalomyelitis. The standard of care for CIPO includes the use of promotility and anti-secretory agents and the resection of the non-functioning gut segment; all of which can cause significant compromise in the quality of life. There is significant evidence that paraneoplastic neurologic syndromes are associated with antibodies directed against certain nerve antigens. We successfully treated a patient with CIPO in the setting of small cell lung cancer with a combination of rituximab and cyclophosphamide. The patient, who had failed to respond to prokinetic agents, anti-secretory therapy, and multiple resections, responded to the immunomodulatory therapy, with minimal residuals with PEG tube feeding and sustained ostomy output. The use of rituximab and cyclophosphamide should therefore be considered in patients with CIPO, especially if it can avoid complicated surgical procedures. |
Databáze: | OpenAIRE |
Externí odkaz: |